Release of N‐Acetylaspartylglutamate from Slices of Rat Cerebellum, Striatum, and Spinal Cord, and the Effect of Climbing Fiber Deprivation
Release of N‐Acetylaspartylglutamate from Slices of Rat Cerebellum, Striatum, and Spinal Cord, and the Effect of Climbing Fiber Deprivation
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大鼠小脑、纹状体和脊髓切片中 N-乙酰天冬氨酰谷氨酸的释放以及攀爬纤维剥夺的影响
DOI：
10.1046/j.1471-4159.1994.63031133.x
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发表时间：
1994
影响因子：
4.7
通讯作者：
M. Cuénod
中科院分区：
文献类型：
--
作者：
M. Zollinger;J. Brauchli;U. Gutteck;K. Do;P. Streit;M. Cuénod
Abstract: The release of endogenous N‐acetylaspartylglutamate (NAAG) from slices of rat cerebellum, striatum, and spinal cord upon depolarization with 50 mM K+ was investigated. NAAG in superfusates was prepurified using an ion exchanger, esterified, and then quantified by gas chromatography‐mass spectrometry. Deuterated NAAG was used as internal standard. A depolarization‐induced release of NAAG was found in all three regions. The release was Ca2+ dependent to over 85% in cerebellum and striatum, but only to approximately 70% in spinal cord. In addition, the effect of lesions of the olivocerebellar pathway on the K+‐induced release of NAAG was studied: Treatment of the animals with 3‐acetylpyridine reduced the release of NAAG from cerebellar hemispheres significantly, by about 40% compared with controls. These results suggest that part of the NAAG released from cerebellar slices on depolarization is related to climbing fibers. Implications of these findings concerning possible physiological roles of NAAG in the three CNS regions are discussed.
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影响因子：
2.5
作者：
TROMBLEY, PQ;WESTBROOK, GL
通讯作者：
WESTBROOK, GL
对 N-乙酰基-L-天冬氨酰-L-谷氨酸 (NAAG) 所谓的梨状皮层神经元兴奋的解释。
DOI：
10.1073/pnas.86.23.9602
发表时间：
1989
影响因子：
11.1
作者：
Whittemore,ER;Koerner,JF
通讯作者：
Koerner,JF
显微解剖大鼠脑核和外周组织中 N-乙酰基-天冬氨酰-谷氨酸的定量：新型液相放射免疫测定的结果。
影响因子：
2.9
作者：
Guarda,AS;Robinson,MB;Ory-Lavollée,L;Forloni,GL;Blakely,RD;Coyle,JT
通讯作者：
Coyle,JT
N-乙酰天冬氨酰谷氨酸的神经生物学。
影响因子：
--
作者：
Blakely,RD;Coyle,JT
通讯作者：
Coyle,JT
N-乙酰基-天冬氨酰谷氨酸对大鼠海马切片中N-甲基-D-天冬氨酸刺激的[3H]去甲肾上腺素释放的调节。
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Puttfarcken,PS;Handen,JS;Montgomery,DT;Coyle,JT;Werling,LL
通讯作者：
Werling,LL