The association between cognitive impairment/dementia and albuminuria: a systematic review and meta-analysis.
The association between cognitive impairment/dementia and albuminuria: a systematic review and meta-analysis.
复制标题
认知障碍/痴呆症与蛋白尿之间的关联：系统评价和荟萃分析。
DOI：
10.1007/s10157-021-02127-3
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发表时间：
2022-01
影响因子：
2.3
通讯作者：
Gao B
中科院分区：
文献类型：
--
作者：
Li H;Zhao S;Wang R;Gao B
确定蛋白尿与痴呆或认知障碍之间的关系。进行文献检索以确定截至2019年8月的相关科学研究，包括PubMed/Medline和EMBASE。纳入的研究必须满足以下标准：基于人群的队列研究、病例对照研究或横断面研究；量化蛋白尿与认知障碍或痴呆的关系和报告的优势比（OR），以及相应的95%可信区间（95% CI）。采用随机效应模型进行汇总估计。荟萃分析共纳入16项研究（11项队列研究和5项横断面研究）。根据完全调整后的估计，蛋白尿与认知障碍或痴呆的风险显著升高有关。此外，认知障碍和痴呆也分别存在同样的趋势。此外，阿尔茨海默病（AD）和血管性痴呆（VaD）都与蛋白尿显著相关。蛋白尿与认知障碍和痴呆显著相关。与肾脏疾病进展的早期亚临床时间点相对应，蛋白尿可能是预测未来痴呆发生的潜在因素。在线版本包含补充材料，可在10.1007/s10157-021-02127-3获得。
To identify the association between albuminuria and dementia or cognitive impairment. The literature search was performed to identify relevant scientific studies through August 2019, including PubMed/Medline and EMBASE. For inclusion, the studies had to fulfil the following criteria: population-based cohort, case–control or cross-sectional studies; quantifying an association of albuminuria with cognitive impairment or dementia; and reported odds ratio (OR), and the corresponding 95% confidential interval (95% CI). Random effects model was used to yield pooled estimates. A total of 16 studies (11 cohort studies and five cross-sectional studies) were included in the meta-analyses. Based on the fully adjusted estimates, albuminuria was associated with a significant higher risk of cognitive impairment or dementia. Furthermore, the same trend existed for cognitive impairment and dementia, respectively. In addition, both of Alzheimer’s diseases (AD) and vascular dementia (VaD) were significantly associated with albuminuria. Albuminuria was significantly associated with cognitive impairment and dementia. Corresponding to an earlier subclinical time-point in kidney disease progress, albuminuria may be a potential factor predicting the future occurrence of dementia. The online version contains supplementary material available at 10.1007/s10157-021-02127-3.
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影响因子：
6.3
作者：
O'Hare AM;Walker R;Haneuse S;Crane PK;McCormick WC;Bowen JD;Larson EB
通讯作者：
Larson EB
DOI：
10.2215/cjn.11321112
发表时间：
2013-11-07
影响因子：
9.8
作者：
Barzilay, Joshua I.;Lovato, James F.;Launer, Lenore J.
通讯作者：
Launer, Lenore J.
DOI：
10.1007/s004060200013
发表时间：
2002-04-01
影响因子：
4.7
作者：
Paragh, G;Balla, P;Degrell, I
通讯作者：
Degrell, I
影响因子：
120.7
作者：
LAUNER, LJ;MASAKI, K;HAVLIK, RJ
通讯作者：
HAVLIK, RJ
影响因子：
13.2
作者：
Barzilay, Joshua I.;Fitzpatrick, Annette L.;Kuller, Lewis H.
通讯作者：
Kuller, Lewis H.