Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19.
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19.
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DOI：
10.1007/s00011-023-01722-2
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发表时间：
2023-05
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影响因子：
--
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疲劳是普通人群的一个突出症状，可能发生在病毒感染（包括导致COVID-19的SARS-CoV 2感染）之后。持续三个月以上的慢性疲劳是COVID后综合征（俗称长COVID）的主要症状。长期COVID疲劳的潜在机制尚不清楚。我们假设，COVID-19之前个体的促炎免疫状态导致了长期COVID慢性疲劳的发展。我们分析了来自TwinsUK的N = 1274名社区居住成年人大流行前的IL-6血浆水平，IL-6在持续性疲劳中起关键作用。随后的COVID-19阳性和阴性参与者根据SARS-CoV-2抗原和抗体检测进行分类。使用Chalder疲劳量表评估慢性疲劳。COVID-19阳性的参与者表现出轻微的疾病。慢性疲劳是这一人群中的普遍症状，阳性参与者显著高于阴性参与者（分别为17%和11%; p = 0.001）。慢性疲劳的定性性质，确定个人的问卷调查结果是相似的积极和消极的参与者。大流行前血浆IL-6水平与阴性个体的慢性疲劳呈正相关，但与阳性个体无关。在阳性参与者中，BMI升高与慢性疲劳相关。预先存在的IL-6水平升高可能导致慢性疲劳症状，但与未感染个体相比，轻度COVID-19个体的风险并没有增加。BMI升高也增加了轻度COVID-19患者慢性疲劳的风险，与之前的报告一致。
Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-COVID chronic fatigue is driven by the pro-inflammatory immune status of an individual prior to COVID-19. We analyzed pre-pandemic plasma levels of IL-6, which plays a key role in persistent fatigue, in N = 1274 community dwelling adults from TwinsUK. Subsequent COVID-19-positive and -negative participants were categorized based on SARS-CoV-2 antigen and antibody testing. Chronic fatigue was assessed using the Chalder Fatigue Scale. COVID-19-positive participants exhibited mild disease. Chronic fatigue was a prevalent symptom among this population and significantly higher in positive vs. negative participants (17% vs 11%, respectively; p = 0.001). The qualitative nature of chronic fatigue as determined by individual questionnaire responses was similar in positive and negative participants. Pre-pandemic plasma IL-6 levels were positively associated with chronic fatigue in negative, but not positive individuals. Raised BMI was associated with chronic fatigue in positive participants. Pre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports.
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影响因子：
11
作者：
Milaneschi Y;Kappelmann N;Ye Z;Lamers F;Moser S;Jones PB;Burgess S;Penninx BWJH;Khandaker GM
通讯作者：
Khandaker GM
影响因子：
6.9
作者：
Cho HJ;Kivimäki M;Bower JE;Irwin MR
通讯作者：
Irwin MR
影响因子：
--
作者：
Lim, WJ;Hong, S;Dimsdale, JE
通讯作者：
Dimsdale, JE
影响因子：
3.7
作者：
Townsend L;Dyer AH;Jones K;Dunne J;Mooney A;Gaffney F;O'Connor L;Leavy D;O'Brien K;Dowds J;Sugrue JA;Hopkins D;Martin-Loeches I;Ni Cheallaigh C;Nadarajan P;McLaughlin AM;Bourke NM;Bergin C;O'Farrelly C;Bannan C;Conlon N
通讯作者：
Conlon N
DOI：
10.1375/twin.4.6.464
发表时间：
2001-12-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Andrew, T;Hart, D J;MacGregor, A J
通讯作者：
MacGregor, A J