Postmortem candidaemia: marker of disseminated disease.
Postmortem candidaemia: marker of disseminated disease.
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DOI：
10.1136/jcp.2009.070607
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发表时间：
2010-04
影响因子：
3.4
通讯作者：
Klotz SA
中科院分区：
文献类型：
--
作者：
Thorn JL;Gilchrist KB;Sobonya RE;Gaur NK;Lipke PN;Klotz SA
尸检时在心血培养中发现念珠菌的意义从未被研究过。因此，我们描述了死后念珠菌血症的尸检患者的发现，并将其与死前念珠菌血症的尸检患者进行比较。在十年的时间里，从尸检时从心脏血液中分离出的23名念珠菌患者被鉴定出来。将这些患者与同期发现的10名尸检患者进行比较，这些患者死前血培养分离出念珠菌种类，但死后心脏血培养未呈阳性。检查了死前和死后的记录。所有23例死后血培养分离的念珠菌感染患者生前均有一个或多个播散性念珠菌病的危险因素，如生前血培养阳性、从无菌内部部位分离念珠菌、中性粒细胞减少症、近期腹部手术、广谱抗生素应用或使用中心静脉导管或其他侵入性装置。8例患者除心脏血培养阳性外，还有侵袭性念珠菌病的组织学证据。在10例播散性念珠菌病尸检患者和生前血培养念珠菌感染患者中，这组患者在危险因素方面没有不同。然而，所有生前念珠菌血症的患者在尸检中都有播散性念珠菌病的组织学证据。假丝酵母菌感染是播散性念珠菌病的一种不敏感但高度特异的指标，当通过尸检时进行的心血培养或生前血液培养来记录时。
The significance of finding Candida species in heart blood cultures obtained at postmortem examination has never been studied. Therefore, we describe the findings of autopsy patients with postmortem candidemia and compare them to autopsy patients with antemortem candidemia. Twenty-three patients with Candida species isolated from heart blood at autopsy were identified over a ten-year period. These patients were compared to 10 autopsy patients found during the same time period with antemortem blood cultures isolating Candida species, but not positive postmortem heart blood cultures. Ante- and postmortem records were reviewed. All 23 patients with Candida species isolated from postmortem blood culture had one or more antemortem risk factors for disseminated candidiasis such as positive antemortem blood cultures, isolation of Candida from sterile internal sites, neutropenia, recent abdominal surgery, broadspectrum antibiotic administration or the use of central venous catheters or other invasive devices. Eight patients had histologic proof of invasive candidiasis in addition to the positive heart blood cultures. This group did not differ with respect to risk factors from 10 autopsy patients with disseminated candidiasis and antemortem blood cultures with Candida species. However, all the patients with antemortem candidemia had histologic evidence of disseminated candidiasis at autopsy. Candidemia, when documented by heart blood culture performed at autopsy or by antemortem blood culture, is an insensitive, but highly specific indicator of disseminated candidiasis.
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影响因子：
2
作者：
Sastre, JBL;Cotallo, GDC;Colomer, BF
通讯作者：
Colomer, BF
DOI：
10.1164/ajrccm.156.2.9612023
发表时间：
1997-08-01
影响因子：
24.7
作者：
ElEbiary, M;Torres, A;deAnta, MTJ
通讯作者：
deAnta, MTJ
影响因子：
9.4
作者：
Ahmad, S;Khan, Z;Khan, ZU
通讯作者：
Khan, ZU
影响因子：
3.3
作者：
Hove, M;Pencil, SD
通讯作者：
Pencil, SD
影响因子：
3.6
作者：
HUGHES, WT
通讯作者：
HUGHES, WT