Regulation of electroneutral NaCl absorption by the small intestine.
Regulation of electroneutral NaCl absorption by the small intestine.
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DOI：
10.1146/annurev-physiol-012110-142244
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发表时间：
2011
影响因子：
18.2
通讯作者：
Romero MF
中科院分区：
文献类型：
--
作者：
Kato A;Romero MF
Na+和Cl−在肠上皮中的移动通过几种相互关联的机制发生：（1）营养耦合的Na+吸收;（2）电中性NaCl吸收;（3）CFTR的产电Cl−分泌;（4）ENaC的产电Na+吸收。所有这些转运模式都需要由基底外侧Na+-K+-ATP酶、Cl−通道和K+通道维持的有利的电化学梯度。从小肠到远端结肠观察到电中性NaCl吸收。这种转运由顶端Na+/H+（NHE 2/3）和Cl−/HCO 3 −（Slc 26 a3/a6，其他）交换剂介导，这些交换剂提供了NaCl吸收的主要途径。CFTR的电中性NaCl吸收和Cl−分泌受自主神经系统、免疫系统和内分泌系统通过PKAα、PKCα、cGKII和/或SGK 1的相反调节。这种整合调节需要形成大分子复合物，其由NHERF家族的支架蛋白介导，并涉及NHE 3的内化。使用基因敲除小鼠和人类突变，一个更详细的了解，以及微妙的调节哺乳动物肠道的电中性NaCl吸收已经出现。
Na+ and Cl− movement across the intestinal epithelium occurs by several interconnected mechanisms: (1) nutrient coupled Na+ absorption; (2) electroneutral NaCl absorption; (3) electrogenic Cl− secretion by CFTR; and (4) electrogenic Na+ absorption by ENaC. All of these transport modes require a favorable electrochemical gradient maintained by the basolateral Na+-K+-ATPase, a Cl− channel and K+ channels. Electroneutral NaCl absorption is observed from the small intestine to distal colon. This transport is mediated by apical Na+/H+ (NHE2/3) and Cl−/HCO3 − (Slc26a3/a6, others) exchangers that provide the major route of NaCl absorption. Electroneutral NaCl absorption and Cl− secretion by CFTR are oppositely regulated by the autonomic nerve system, immune system, and endocrine system via PKAα, PKCα, cGKII, and/or SGK1. This integrated regulation requires the formation of macromolecular complexes, which mediated by NHERF family of scaffold proteins, and involve internalization of NHE3. Using knockout mice and human mutations, a more detailed understanding of the integrated as well as subtle regulation of electroneutral NaCl absorption by the mammalian intestine has emerged.
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DOI：
10.1152/ajpgi.00332.2003
发表时间：
2004-07-01
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
2.4
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影响因子：
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影响因子：
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作者：
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