Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population.
Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population.
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ROCK2多态性与中国人群心血管疾病的关联分析
DOI：
10.1371/journal.pone.0053905
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang DW
中科院分区：
文献类型：
--
作者：
Liu L;Cao Y;Cui G;Li Z;Sun J;Zhang L;Chen C;Wang Y;Wang P;Ding H;Wang DW
背景：Rho-Kinase(ROCK)在冠心病、高血压等心血管疾病中起重要作用。最近，常见的ROCK2基因变异被报道会影响血压，但在中国人群中，常见的ROCK2基因变异与心血管疾病的关系尚未得到广泛研究。方法通过对ROCK2基因所有外显子的直接测序筛选常见变异，然后在一项CAD病例对照研究中进行遗传关联分析，包括1344例病例和1267名种族和地理匹配的对照。结果非条件Logistic回归分析显示，ROCK2基因编码区常见变异与冠心病无显著关联(rs978906，OR = 0.92，95%CI 0.72~1.20，P = 0.63；rs2230774，OR = 0.90，95%CI 0.70~1.16，P = 0.47；rs56304104，OR = 0.97，95%CI 0.70~1.31，P = 0.83)。结论ROCK2基因多态性与心血管疾病风险的关系不能完全打折扣，值得在大范围人群中进一步评估。
Background Rho-kinase (ROCK) has been shown to play an important role in cardiovascular disease such as coronary artery disease (CAD) and hypertension. Recently, common variants of ROCK2 have been reported to influence blood pressure, but the relationship between common ROCK2 variants and cardiovascular disease has not been extensively studied in the Chinese population. Methods To derive a more precise estimation of their relationship, we screened for the common variants by direct sequencing of all exons of ROCK2, and then we performed genetic association analyses in a CAD case–control study, including a total of 1344 cases and 1267 ethnically and geographically matched controls. Results Unconditional logistic regression showed that no significant association between common variants in the coding region of ROCK2 and CAD was observed in our study (for rs978906, OR = 0.92, 95% CI 0.72–1.20 and P = 0.63; for rs2230774, OR = 0.90, 95% CI 0.70–1.16 and P = 0.47; for rs56304104, OR = 0.97, 95% CI 0.70–1.31 and P = 0.83; respectively). Conclusions The relationship between the ROCK2 polymorphisms and cardiovascular disease risk cannot be entirely discounted and warrants further evaluation in a large population.
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影响因子：
3.2
作者：
Kuo, Tai-Yue;Kang, Mei-Jyh;Pan, Wen-Harn
通讯作者：
Pan, Wen-Harn
影响因子：
2.6
作者：
Ding H;Cui G;Zhang L;Xu Y;Bao X;Tu Y;Wu B;Wang Q;Hui R;Wang W;Dackor RT;Kissling GE;Zeldin DC;Wang DW
通讯作者：
Wang DW
影响因子：
3
作者：
Inokuchi, K;Ito, A;Shimokawa, H
通讯作者：
Shimokawa, H
影响因子：
39.3
作者：
Montorsi, Piero;Ravagnani, Paolo M.;Fiorentini, Cesare
通讯作者：
Fiorentini, Cesare
影响因子：
1.7
作者：
Guérin, P;Sauzeau, V;Loirand, G
通讯作者：
Loirand, G