Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences
Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences
复制标题
人类股骨中轴皮质内孔隙度的区域差异：年龄和性别差异
作者：
C. Thomas;S. Feik;J. Clement
本研究调查了年龄和性别差异的模式孔隙分布在人体股骨中段。从现代澳大利亚人群的168个个体中获得横截面。样本包括73名女性和95名男性，年龄在20至97岁之间。用100 µm切片制作显微放射照片，并使用图像处理软件确定孔隙和骨面积。最初，样本按年龄划分：年轻（20-44岁）、中年（45-64岁）和老年（65岁以上），但发现基于骨髓面积与总骨膜下面积之比的分析得到了更清晰的结果。将皮质径向分为三个环，周向分为八分区，并计算每个区段的孔隙度。结果表明，随着年龄的增长，后外侧和前外侧区域的孔隙度升高，皮质内部孔隙度更大的模式变得更加明显。在男性中，这种模式稳步发展;在女性中，中年和老年群体之间的差异比生命早期要大得多。观察到的模式与沿着皮质中性轴发生的进行性骨丢失一致，其中弯曲应力最低，骨的机械优势最小。
This study investigated age and sex differences in patterns of porosity distribution in the midshaft of the human femur. Cross‐sections were obtained from 168 individuals from a modern Australian population. The sample comprised 73 females and 95 males, aged between 20 and 97 years. Microradiographs were made of 100‐µm sections and pore and bone areas were determined using image processing software. Initially the sample was divided by age: young (20–44 years), middle (45–64 years) and old (65+ years), but it was found that analysis on the basis of the ratio of medullary area to total subperiosteal area gave clearer results. The cortex was divided into three rings radially and into octants circumferentially and the porosity of each segment was calculated. Results showed that a pattern with raised porosity in the posterior and anterolateral regions, and with greater porosity in the inner parts of the cortex, becomes more pronounced with age. In males this pattern develops steadily; in females there are much greater differences between the middle and older groups than earlier in life. The patterns observed are consistent with progressive bone loss occurring along a neutral axis of the cortex where bending stress is lowest and the mechanical advantage of the bone is least.
遗传对生物衰老的贡献：弗雷明汉研究。
DOI：
10.1093/gerona/59.3.b218
发表时间：
2004
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Karasik,David;Hannan,MarianT;Cupples,LAdrienne;Felson,DavidT;Kiel,DouglasP
通讯作者：
Kiel,DouglasP
影响因子：
4.1
作者：
L. Melton
通讯作者：
L. Melton
影响因子：
2.4
作者：
SCHAFFLER, MB;BURR, DB
通讯作者：
BURR, DB