TAM receptor deficiency affects adult hippocampal neurogenesis.
TAM receptor deficiency affects adult hippocampal neurogenesis.
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DOI：
10.1007/s11011-014-9636-y
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发表时间：
2015-06
影响因子：
3.6
通讯作者：
Lu Q
中科院分区：
文献类型：
--
作者：
Ji R;Meng L;Li Q;Lu Q
The Tyro3, Axl and Mertk (TAM) subfamily of receptor protein tyrosine kinases functions in cell growth, differentiation, survival, and most recently found, in the regulation of immune responses and phagocytosis. All three receptors and their ligands, Gas6 (growth arrest-specific gene 6) and protein S, are expressed in the central nervous system (CNS). TAM receptors play pivotal roles in adult hippocampal neurogenesis. Loss of these receptors causes a comprised neurogenesis in the dentate gyrus of adult hippocampus. TAM receptors have a negative regulatory effect on microglia and peripheral antigen-presenting cells, and play a critical role in preventing overproduction of pro-inflammatory cytokines detrimental to the proliferation, differentiation, and survival of adult neuronal stem cells (NSCs). Besides, these receptors also play an intrinsic trophic function in supporting NSC survival, proliferation, and differentiation into immature neurons. All these events collectively ensure a sustained neurogenesis in adult hippocampus.
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影响因子：
20.1
作者：
D'Arcangelo, D;Gaetano, C;Capogrossi, MC
通讯作者：
Capogrossi, MC
DOI：
10.1016/j.jalz.2010.12.014
发表时间：
2011-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Breitner JC;Baker LD;Montine TJ;Meinert CL;Lyketsos CG;Ashe KH;Brandt J;Craft S;Evans DE;Green RC;Ismail MS;Martin BK;Mullan MJ;Sabbagh M;Tariot PN;ADAPT Research Group
通讯作者：
ADAPT Research Group
影响因子：
9.3
作者：
Bachstetter, Adam D.;Xing, Bin;Van Eldik, Linda J.
通讯作者：
Van Eldik, Linda J.
影响因子：
5.5
作者：
Anwar, Adil;Keating, Amy K.;Graham, Douglas K.
通讯作者：
Graham, Douglas K.
影响因子：
--
作者：
Allen, MP;Zeng, C;Wierman, ME
通讯作者：
Wierman, ME