Novel avenues to control blood pressure: targeting the renal lymphatic system.
Novel avenues to control blood pressure: targeting the renal lymphatic system.
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DOI：
10.1042/cs20220775
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发表时间：
2023-04-26
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
高血压与免疫和淋巴系统的激活以及淋巴管生成有关。淋巴系统的变化被认为是一种适应性反应，以减轻免疫和炎症细胞对心血管系统的有害影响。在Goodlett及其合作者最近发表在《临床科学》上的文章中，有证据表明，在小鼠建立高血压后诱导肾淋巴管生成是降低全身动脉血压的有效策略。在这篇评论中，我们将简要回顾免疫和淋巴系统激活之间的关系，以及对全身血压的影响，总结Goodlett及其合作者发表的研究结果，并讨论他们的研究结果对该领域的影响。
Hypertension is associated with the activation of the immune and lymphatic systems as well as lymphangiogenesis. The changes in the lymphatic system are considered an adaptive response to mitigate the deleterious effects of immune and inflammatory cells on the cardiovascular system. In the article recently published in Clinical Science by Goodlett and collaborators, evidence is shown that inducing renal lymphangiogenesis after the establishment of hypertension in mice is an effective maneuver to reduce systemic arterial blood pressure. In this commentary, we will briefly review what is known about the relationship between the activation of the immune and lymphatic systems, and the resulting effects on systemic blood pressure, summarize the findings published by Goodlett and collaborators, and discuss the impact of their findings on the field.
影响因子：
3.9
作者：
Reis A;Rocha S;de Freitas V
通讯作者：
de Freitas V