Going "Green" in the Prevention and Management of Atherothrombotic Diseases: The Role of Dietary Polyphenols.
Going "Green" in the Prevention and Management of Atherothrombotic Diseases: The Role of Dietary Polyphenols.
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走向“绿色”在预防和管理动脉粥样硬化血栓形成疾病：膳食多酚的作用。
DOI：
10.3390/jcm10071490
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发表时间：
2021-04-03
影响因子：
3.9
通讯作者：
de Freitas V
中科院分区：
文献类型：
--
作者：
Reis A;Rocha S;de Freitas V
在20世纪世纪，加工食品和即食食品成为日常消费，导致人们饮食中脂肪、盐和糖的摄入量急剧上升。目前，全球肥胖症、血脂升高、高血压和糖尿病在日益老龄化的人群中的发病率导致动脉粥样硬化血栓形成事件和心血管疾病（CVD）死亡率上升。基于药物的治疗是解决和帮助管理动脉粥样硬化血栓形成疾病的社会经济影响的有价值的策略，尽管并非没有不良副作用。按照世卫组织的建议，将富含类黄酮的新鲜水果和蔬菜纳入人类饮食提供了一种宝贵的营养战略，可替代药物治疗，在早期阶段预防和管理动脉粥样硬化血栓形成疾病方面有待探索。虽然多酚主要与食物的颜色和味道有关，但食物类黄酮正在成为胆固醇生物合成，食欲和食物摄入，血压，血小板功能，凝块形成和抗炎信号的调节剂，支持富含多酚的饮食在减轻动脉粥样硬化血栓形成疾病和CVD事件中风险因素的影响方面的健康促进作用。在这里，我们概述了目前的知识，尤其是类黄酮摄入量对动脉粥样硬化血栓形成的危险因素的影响，并讨论了目前的实验性细胞为基础的设计所涉及的警告和挑战。
During the 20th century processed and ready-to-eat foods became routinely consumed resulting in a sharp rise of fat, salt, and sugar intake in people’s diets. Currently, the global incidence of obesity, raised blood lipids, hypertension, and diabetes in an increasingly aged population contributes to the rise of atherothrombotic events and cardiovascular diseases (CVD) mortality. Drug-based therapies are valuable strategies to tackle and help manage the socio-economic impact of atherothrombotic disorders though not without adverse side effects. The inclusion of fresh fruits and vegetables rich in flavonoids to human diets, as recommended by WHO offers a valuable nutritional strategy, alternative to drug-based therapies, to be explored in the prevention and management of atherothrombotic diseases at early stages. Though polyphenols are mostly associated to color and taste in foods, food flavonoids are emerging as modulators of cholesterol biosynthesis, appetite and food intake, blood pressure, platelet function, clot formation, and anti-inflammatory signaling, supporting the health-promoting effects of polyphenol-rich diets in mitigating the impact of risk factors in atherothrombotic disorders and CVD events. Here we overview the current knowledge on the effect of polyphenols particularly of flavonoid intake on the atherothrombotic risk factors and discuss the caveats and challenges involved with current experimental cell-based designs.
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影响因子：
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作者：
Atrahimovich D;Khatib S;Sela S;Vaya J;Samson AO
通讯作者：
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