Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
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DOI：
10.1016/j.immuni.2015.03.014
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发表时间：
2015-04-21
期刊：
影响因子：
32.4
通讯作者：
Nagao, Keisuke
中科院分区：
文献类型：
--
作者：
Kobayashi, Tetsuro;Glatz, Martin;Horiuchi, Keisuke;Kawasaki, Hiroshi;Akiyama, Haruhiko;Kaplan, Daniel H.;Kong, Heidi H.;Amagai, Masayuki;Nagao, Keisuke
金黄色葡萄球菌的皮肤定植在特应性皮炎中是普遍的，在表皮生长因子受体抑制剂治疗的癌症患者中也很常见。然而，生态失调与湿疹的因果关系尚不清楚。在此，我们证明了Adam17fl/flSox9-Cre小鼠，用于模拟人类adam17缺乏症，发展为湿疹性皮炎并伴有自然发生的生态失调，与特应性皮炎相似。乳突棒状杆菌、金黄色葡萄球菌和牛棒状杆菌在湿疹性皮炎发病期间依次出现，这些细菌的特异性抗生素几乎完全逆转了生态失调并消除了皮肤炎症。金黄色葡萄球菌显著地促进了湿疹的形成，而牛葡萄球菌诱导了强大的辅助性T - 2细胞反应。朗格汉斯细胞是引发对金黄色葡萄球菌接种的免疫反应所必需的。这些结果表征了在湿疹形成过程中不同的生态失调菌群，并强调了微生物-宿主免疫轴作为湿疹性皮炎未来治疗的可能靶点。
Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal relationship of dysbiosis and eczema has yet to be clarified. Herein, we demonstrate that Adam17fl/flSox9-Cre mice, generated to model ADAM17-deficiency in human, developed eczematous dermatitis with naturally occurring dysbiosis, similar to that observed in atopic dermatitis. Corynebacterium mastitidis, S. aureus, and Corynebacterium bovis sequentially emerged during the onset of eczematous dermatitis, and antibiotic specific for these bacterial species almost completely reversed dysbiosis and eliminated skin inflammation. Whereas S. aureus prominently drove eczema formation, C. bovis induced robust T helper 2 cell responses. Langerhans cells were required for eliciting immune responses against S. aureus inoculation. These results characterize differential contributions of dysbiotic flora during eczema formation, and highlight the microbiota-host immunity axis as a possible target for future therapeutics in eczematous dermatitis.
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DOI：
10.1084/jem.20112258
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Franzke CW;Cobzaru C;Triantafyllopoulou A;Löffek S;Horiuchi K;Threadgill DW;Kurz T;van Rooijen N;Bruckner-Tuderman L;Blobel CP
通讯作者：
Blobel CP
影响因子：
15.9
作者：
Leung, Thomas H.;Zhang, Lillian F.;Kim, Seung K.
通讯作者：
Kim, Seung K.
影响因子：
13.8
作者：
Eichenfield, Lawrence F.;Tom, Wynnis L.;Berger, Timothy G.;Krol, Alfons;Paller, Amy S.;Schwarzenberger, Kathryn;Bergman, James N.;Chamlin, Sarah L.;Cohen, David E.;Cooper, Kevin D.;Cordoro, Kelly M.;Davis, Dawn M.;Feldman, Steven R.;Hanifin, Jon M.;Margolis, David J.;Silverman, Robert A.;Simpson, Eric L.;Williams, Hywel C.;Elmets, Craig A.;Block, Julie;Harrod, Christopher G.;Begolka, Wendy Smith;Sidbury, Robert
通讯作者：
Sidbury, Robert
影响因子：
10.3
作者：
LEYDEN, JJ;MARPLES, RR;KLIGMAN, AM
通讯作者：
KLIGMAN, AM
影响因子：
10.3
作者：
Eilers, R. E., Jr.;Gandhi, M.;Lacouture, Mario E.
通讯作者：
Lacouture, Mario E.