A descriptive study of Parkinson disease and atypical parkinsonisms in the Annuals of the Pathological Autopsy Cases in Japan
A descriptive study of Parkinson disease and atypical parkinsonisms in the Annuals of the Pathological Autopsy Cases in Japan
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日本病理尸检年鉴中帕金森病和非典型帕金森病的描述性研究
DOI：
10.1111/neup.12876
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发表时间：
2022
期刊：
影响因子：
2.3
通讯作者：
Inagaki Hiroshi
中科院分区：
文献类型：
--
作者：
Horimoto Yoshihiko;Sato Chikako;Anan Chise;Suzuki Ayuko;Inagaki Aki;Tajima Toshihisa;Hibino Hiroaki;Inagaki Hiroshi
虽然在帕金森病(PD)和非典型帕金森综合征的广泛范围内已经建立了许多实体，但它们通常很难区分。为了阐明帕金森病和非典型帕金森综合征的临床诊断现状和存在的问题，我们分析了日本大量的病理尸检病例。在2007年至2016年在日本各地进行的130例 105尸检中，如果患者被临床或病理诊断为帕金森病、多系统萎缩、进行性核上性瘫痪或皮质基底膜变性，则纳入研究。临床诊断为PD的尸检率为6.4%，MSA为34.1%，PSP为16.3%，CBD为17.4%。临床诊断PD、MSA、PSP、CBD的特异度和敏感度分别为88.0%和82.0%、95.2%和86.0%、82.7%和73.2%、55.4%和57.7%。临床诊断的准确性相对较高，但尸检率较低令人担忧。许多患有罕见疾病的患者在临床上被误诊为帕金森病，这是一种更常见的疾病。尸检率，无论具体疾病，应该提高，以发现罕见的疾病。尸检率的提高将增加有关经病理确认的患者的可用临床信息，并有助于更准确的临床诊断。
Although many entities have been established within the broad spectrum of Parkinson disease (PD) and atypical parkinsonisms, they are often difficult to differentiate. To clarify the current clinical diagnostic conditions and problems in PD and atypical parkinsonisms, we analyzed volumes of theAnnuals of the Pathological Autopsy Cases in Japan. Among 130 105 autopsies conducted from 2007 to 2016 throughout Japan, patients were included in the study if they had been either clinically or pathologically diagnosed with PD, multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal degeneration (CBD). Autopsy rates were 6.4% for clinically diagnosed PD, 34.1% for MSA, 16.3% for PSP, and 17.4% for CBD. The specificities and sensitivities of clinical diagnoses were 88.0% and 82.0% for PD, 95.2% and 86.0% for MSA, 82.7% and 73.2% for PSP, and 55.4% and 57.7% for CBD, respectively. Clinical diagnoses had relatively high accuracy, but low autopsy rates are of concern. Many patients with rarer disorders were clinically misdiagnosed with PD, a more common disorder. Autopsy rates, irrespective of specific disorders, should be increased to detect rare diseases. Increasing autopsy rates will increase the available clinical information regarding pathologically confirmed patients and contribute to more accurate clinical diagnoses.
影响因子：
9.9
作者：
Katzenschlager, R.;Head, J.;Lees, A. J.
通讯作者：
Lees, A. J.
《日本病理尸检年鉴》中报道的朊病毒病
影响因子：
4.4
作者：
Horimoto Yoshihiko;Sato Chikako;Inagaki Aki;Tajima Toshihisa;Hibino Hiroaki;Kabasawa Hidehiro;Inagaki Hiroshi
通讯作者：
Inagaki Hiroshi
影响因子：
3.7
作者：
Hong JY;Sunwoo MK;Oh JS;Kim JS;Sohn YH;Lee PH
通讯作者：
Lee PH