HIV-1 entry and how to block it.-猫眼课题宝

HIV-1 进入以及如何阻止它。

DOI：

10.1097/00002030-200100005-00002

发表时间：

2001

期刊：

AIDS

影响因子：

3.8

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

A. Brelot;M. Alizon

在过去的几年里，我们对HIV进入细胞并开始复制的过程的理解有了很大的发展。其中最引人注目的成就是鉴定了作为病毒受体的新细胞因子，阐明了病毒包膜蛋白的至少部分空间结构，并发现了有效阻断细胞进入过程的化合物。知识以前所未有的速度增长，使得自大约20年前艾滋病出现以来遗留的问题得到了解答。在这篇简短的文章中，我们将尝试总结这一HIV研究领域的最新进展，并根据这些新发现讨论抗病毒策略的前景。但是，我们也要表明，一些重要的问题仍然没有得到解决。将要讨论的问题代表了在HIV进入研究领域中可能是任意选择的，其中最近和优秀的评论都是可用的[1-3]。我们的重点是1型病毒（HIV-1），与相关的人类（HIV-2）猿或猫免疫缺陷病毒相比，它有更多的信息。(摘录)

Our understanding of the process by which the HIV enters cells and initiates its replication has considerably evolved over the past few years. Among the most spectacular achievements are the identification of novel cellular factors behaving as viral receptors the elucidation at least partial of the spatial structure of the viral envelope proteins and the discovery of compounds efficiently blocking the cell entry process. Knowledge has been growing at an unprecedented pace allowing questions left open since the HIV disease emerged some 20 years ago to meet their answer. In this brief article we shall attempt to summarize the recent evolution of this field of HIV research and discuss the promises of antiviral strategies based on the novel findings. But we also would like to show that a number of important questions remain unsolved. The issues that will be discussed represent a selection perhaps arbitrary within the research field of HIV entry for which both recent and excellent reviews are available [1-3]. We focus on the type 1 virus (HIV-1) for which there is considerably more information than for the related human (HIV-2) simian or feline immunodeficiency viruses. (excerpt)