Unenhanced region on magnetic resonance imaging represents tumor progression in uterine carcinosarcoma.
Unenhanced region on magnetic resonance imaging represents tumor progression in uterine carcinosarcoma.
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DOI：
10.3802/jgo.2017.28.e62
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发表时间：
2017-09
影响因子：
3.9
通讯作者：
Matsumura N
中科院分区：
文献类型：
--
作者：
Inoue A;Yamaguchi K;Kurata Y;Murakami R;Abiko K;Hamanishi J;Kondoh E;Baba T;Kido A;Konishi I;Matsumura N
子宫体癌肉瘤预后差。虽然病理性坏死是子宫内膜癌的一个预后因素，但磁共振成像（MRI）上观察到的无强化区域的临床病理影响尚不确定。我们研究的目的是确定子宫癌肉瘤MRI上出现的非增强区（可代表坏死）的临床生物学影响。对29例子宫癌肉瘤患者的临床病理因素进行回顾性分析。确定MRI上未增强肿瘤的百分比。分析与无强化区相关的临床病理因素。采用Kaplan-Meier法和考克斯回归模型分析其预后意义。尽管病理性坏死的存在不是不良预后因素（p = 0.704），但当肿瘤中的未增强区域占总肿瘤的10%以上时，MRI上的未增强区域与不良预后相关（p = 0.019）。无强化区的百分比与分期呈正相关（p = 0.028; r = 0.4691），与肿瘤大小相关（p = 0.086; r = 0.3749）。考克斯回归分析表明，淋巴结（LN）转移的存在和超过10%的肿瘤在MRI上未增强是单变量分析中总生存率的预后因素（分别为p = 0.018和p = 0.047）。MRI上的无强化区域代表病理性坏死，反映了肿瘤的进展，该区域的半定量有助于预测子宫癌肉瘤患者的预后。
Carcinosarcoma of the uterine corpus has a poor prognosis. Although pathological necrosis is a prognostic factor of endometrial cancer, the clinicopathological influences of an unenhanced region observed on magnetic resonance imaging (MRI) are inconclusive. The aim of our study was to determine the clinicobiological impact of the presence of an unenhanced region on MRI, which can represent necrosis, in uterine carcinosarcoma. The clinicopathological factors of 29 patients diagnosed with uterine carcinosarcoma were assessed retrospectively. The percentage of the tumor that was unenhanced on MRI was determined. The clinicopathological factors related to the unenhanced regions were evaluated. The prognostic significance was assessed using the Kaplan-Meier method and Cox regression model. Although the presence of pathological necrosis was not a poor prognostic factor (p=0.704), unenhanced regions on MRI correlated with poor prognosis when the unenhanced regions in the tumor accounted for more than 10% of the total tumor (p=0.019). The percentage of unenhanced regions was positively correlated with stage (p=0.028; r=0.4691) and related to tumor size (p=0.086; r=0.3749). The Cox regression analysis indicated that the presence of lymph node (LN) metastasis and more than 10% of the tumor being unenhanced on MRI were prognostic factors of overall survival in the univariate analyses (p=0.018 and p=0.047, respectively). The unenhanced region on MRI, which represents pathological necrosis, reflects tumor progression, and semi-quantification of the region is useful to predict the prognosis in patients with uterine carcinosarcoma.
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DOI：
10.1016/j.ejogrb.2008.12.014
发表时间：
2009-04-01
影响因子：
2.6
作者：
Galaal, K.;Kew, F. M.;Edmondson, R. J.
通讯作者：
Edmondson, R. J.
影响因子：
4.4
作者：
Tanaka, Yumiko O.;Tsunoda, Hajime;Minami, Manabu
通讯作者：
Minami, Manabu
影响因子：
3.8
作者：
Seeber LM;Horrée N;van der Groep P;van der Wall E;Verheijen RH;van Diest PJ
通讯作者：
van Diest PJ
影响因子：
3.3
作者：
Pollheimer, Marion J.;Kornprat, Peter;Langner, Cord
通讯作者：
Langner, Cord
影响因子：
2.1
作者：
Takemori, M;Nishimura, R;Sugimura, K
通讯作者：
Sugimura, K