Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma.
Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma.
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DOI：
10.1186/1471-2407-10-307
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发表时间：
2010-06-19
期刊：
影响因子：
3.8
通讯作者：
van Diest PJ
中科院分区：
文献类型：
--
作者：
Seeber LM;Horrée N;van der Groep P;van der Wall E;Verheijen RH;van Diest PJ
缺氧诱导因子1α（HIF-1α）在细胞对缺氧的适应性反应中起重要作用，并与肿瘤的侵袭性行为有关。我们已经表明，p27 kip 1，这是普遍减少子宫内膜癌，重新表达在缺氧区域。这可能有助于癌细胞的生存。本研究旨在探讨HIF-1α和p27 kip在子宫内膜样癌中的表达及其与预后的关系。免疫组化法检测HIF-1α、CAIX、Glut-1和p27 kip 1的表达水平。记录阳性细胞百分比、染色模式（周围坏死、弥漫性或混合性）和坏死的存在。坏死与缩短的无病生存期（DFS）（p = 0.008）和总生存期（OS）（p = 0.045）相关。对于DFS，围坏死期HIF-1α表达也具有预后意义（p = 0.044）。此外，p27 kip 1高表达是这些围坏死期HIF-1α表达患者的额外预后因素。在多变量考克斯回归分析中，坏死周HIF表达是一个独立的预后因素。坏死周HIF-1α表达与CAIX和Glut-1表达显著相关，指向功能性HIF-1。在子宫内膜样癌患者中，坏死和坏死相关HIF-1α表达是重要的预后因素。更积极的辅助治疗可能是必要的，以改善这些特征的患者的结果。
Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27kip1, which is generally reduced in endometrial cancer, to be re-expressed in hypoxic regions. This possibly contributes to survival of cancer cells. The aim of this study was to evaluate the prognostic value of HIF-1α and p27kip expression in patients with endometrioid endometrial cancer. Expression levels of HIF-1α, CAIX, Glut-1, and p27kip1 were analyzed by immunohistochemistry. Percentage of positive cells, staining pattern (perinecrotic, diffuse, or mixed) and presence of necrosis were noted. Necrosis was correlated with shortened disease free survival (DFS) (p = 0.008) and overall survival (OS) (p = 0.045). For DFS, perinecrotic HIF-1α expression was also prognostic (p = 0.044). Moreover, high p27kip1 expression was an additional prognostic factor for these patients with perinecrotic HIF-1α expression. In multivariate Cox regression, perinecrotic HIF-expression emerged as an independent prognostic factor. Perinecrotic HIF-1α expression was significantly associated with CAIX and Glut-1 expression, pointing towards functional HIF-1. In patients with endometrioid endometrial cancer, necrosis and necrosis-related expression of HIF-1α are important prognostic factors. More aggressive adjuvant treatment might be necessary to improve the outcome of patients with these characteristics.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
3.3
作者：
Osada, Ryosuke;Horiuchi, Akiko;Konishi, Ikuo
通讯作者：
Konishi, Ikuo
DOI：
10.1111/j.1525-1438.2006.00541.x
发表时间：
2006-05-01
影响因子：
4.8
作者：
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通讯作者：
Demirhan, B.
影响因子：
7.3
作者：
Horree, N.;Gort, E. H.;van Diest, P. J.
通讯作者：
van Diest, P. J.
影响因子：
4.8
作者：
Huang, LE;Arany, Z;Bunn, HF
通讯作者：
Bunn, HF