Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice.
Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice.
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DOI：
10.1016/j.jnutbio.2012.03.001
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Daugherty A
中科院分区：
文献类型：
--
作者：
Lu H;Wu C;Howatt DA;Balakrishnan A;Charnigo RJ Jr;Cassis LA;Daugherty A
膳食钠摄入量调节肾素血管紧张素系统（RAS）和血压，这两者在动脉粥样硬化中发挥着关键作用。然而，关于膳食钠摄入量对动脉粥样硬化的影响存在相互矛盾的发现。这项研究应用了广泛的膳食钠浓度来确定膳食钠摄入量对小鼠 RAS、血压和动脉粥样硬化的伴随影响。八周大的雄性低密度脂蛋白受体 -/− 小鼠被喂食含有选定钠浓度（Na 0.01%、0.1% 或 2% w/w）的饱和脂肪丰富饮食，持续 12 周。这三组小鼠均患有高胆固醇血症，尽管饲喂 0.01% 和 0.1% Na 的小鼠血浆胆固醇浓度高于饲喂 2% Na 的小鼠。饲喂 0.01% Na 的小鼠的肾脏肾素 mRNA 丰度高于饲喂 0.1% 和 2% Na 的小鼠。饲喂 Na 0.01% 的小鼠的血浆肾素浓度（14.2±1.7 ng/ml/30 分钟）高于饲喂 Na 0.1% 或 2% 的小鼠（分别为 6.2±0.6 和 5.8±1.6 ng/ml/30 分钟）。然而，12周时，饲喂Na 2%的小鼠的收缩压（138±3 mmHg）高于饲喂Na 0.01%和0.1%的小鼠（分别为129±3和128±4 mmHg）。相比之下，饲喂Na 0.01%（0.17±0.02 mm2）的小鼠主动脉根部动脉粥样硬化病变面积大于饲喂Na 2%（0.09±0.01 mm2）的小鼠，而饲喂Na 0.1%（0.12±0.02 mm2）的小鼠主动脉根部动脉粥样硬化病变面积介于Na 0.01%和Na 2%组之间，且没有显着差异。总之，高膳食钠摄入量会导致高收缩压，而低膳食钠摄入量会加剧高胆固醇血症小鼠的动脉粥样硬化。
The amount of dietary sodium intake regulates the renin angiotensin system (RAS) and blood pressure, both of which play critical roles in atherosclerosis. However, there are conflicting findings regarding the effects of dietary sodium intake on atherosclerosis. This study applied a broad range of dietary sodium concentrations to determine the concomitant effects of dietary sodium intake on the RAS, blood pressure, and atherosclerosis in mice. Eight-week-old male low-density lipoprotein receptor −/− mice were fed a saturated fat-enriched diet containing selected sodium concentrations (Na 0.01%, 0.1%, or 2% w/w) for 12 weeks. Mice in these three groups were all hypercholesterolemic, although mice fed Na 0.01% and Na 0.1% had higher plasma cholesterol concentrations than mice fed Na 2%. Mice fed Na 0.01% had greater abundances of renal renin mRNA than those fed Na 0.1% and 2%. Plasma renin concentrations were higher in mice fed Na 0.01% (14.2±1.7 ng/ml/30 min) than those fed Na 0.1% or 2% (6.2±0.6 and 5.8±1.6 ng/ml per 30 min, respectively). However, systolic blood pressure at 12 weeks was higher in mice fed Na 2% (138±3 mm Hg) than those fed Na 0.01% and 0.1% (129±3 and 128±4 mmHg, respectively). In contrast, mice fed Na 0.01% (0.17±0.02 mm2) had larger atherosclerotic lesion areas in aortic roots than those fed Na 2% (0.09±0.01 mm2), whereas lesion areas in mice fed Na 0.1% (0.12±0.02 mm2) were intermediate between and not significantly different from those in Na 0.01% and Na 2% groups. In conclusion, while high dietary sodium intake led to higher systolic blood pressure, low dietary sodium intake augmented atherosclerosis in hypercholesterolemic mice.
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影响因子：
5.3
作者：
Doran, Derek E.;Weiss, Daiana;Taylor, W. Robert
通讯作者：
Taylor, W. Robert
影响因子：
4.8
作者：
Kouyama, R;Suganami, T;Ogawa, Y
通讯作者：
Ogawa, Y
DOI：
10.1152/ajpendo.00277.2006
发表时间：
2007-05-01
影响因子：
5.1
作者：
Lu, Hong;Boustany-Kari, Carine M.;Cassis, Lisa A.
通讯作者：
Cassis, Lisa A.
DOI：
10.3791/1291
发表时间：
2009-05-15
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
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通讯作者：
Balakrishnan, Anju
影响因子：
8.3
作者：
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