Breast cancer therapies and cardiomyopathy.
Breast cancer therapies and cardiomyopathy.
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DOI：
10.1016/j.mcna.2012.07.008
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发表时间：
2012-09
影响因子：
5.9
通讯作者：
Moslehi, Javid
中科院分区：
文献类型：
--
作者：
Groarke, John;Tong, Dan;Khambhati, Jay;Cheng, Susan;Moslehi, Javid
The advent of modern cancer therapy has considerably improved the outcomes of oncology patients and, for the first time, has introduced survivorship as a theme in the management of patients with cancer. However, both traditional and novel chemotherapies are associated with cardiotoxicity. Increasingly, patients with cancer are older, have cardiovascular comorbidities, have prior exposure to anticancer therapies, and/or have received combinations of agents. These factors can predispose to cardiotoxic effects of chemotherapies and contribute to a growing prevalence of patients with cardiac diseases related to cancer treatments. Cardio-oncology services are emerging internationally to guide optimal management of this challenging patient population.The more common anticancer therapies and their respective cardiotoxicities are outlined in Table 1. This review focuses on cardiomyopathy associated with anthracycline chemotherapies and HER-2 targeted therapies, which together constitute a major subset of referrals to cardio-oncology clinics. Cardiomyopathy in the setting of these agents can range from asymptomatic reversible myocardial injury to irreversible, symptomatic congestive heart failure. Surveillance and management strategies used to identify and treat adverse cardiac effects for these chemotherapies are reviewed. The challenges facing cardiooncologists are also explored, including the lack of consensus guidelines to direct clinical practice.
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DOI：
10.1016/s0735-1097(00)00748-8
发表时间：
2000-08-01
影响因子：
24
作者：
Cardinale, D;Sandri, MT;Fiorentini, C
通讯作者：
Fiorentini, C
影响因子：
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作者：
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通讯作者：
Sawyer, DB
DOI：
10.1152/ajpheart.1999.277.5.h2026
发表时间：
1999-11-01
影响因子：
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作者：
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通讯作者：
Kelly, RA
影响因子：
39.3
作者：
Bellenger, NG;Burgess, MI;Pennell, DJ
通讯作者：
Pennell, DJ
影响因子：
1.4
作者：
Hamada, Hisamitsu;Ohkubo, Takashi;Ogawa, Shunichi
通讯作者：
Ogawa, Shunichi