Cancer based pharmacogenomics network supported with scientific evidences: from the view of drug repurposing.
Cancer based pharmacogenomics network supported with scientific evidences: from the view of drug repurposing.
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DOI：
10.1186/s13040-015-0042-8
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发表时间：
2015
期刊：
影响因子：
4.5
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Wang L;Liu H;Chute CG;Zhu Q
药物基因组学（PGx）作为一个新兴领域，正准备通过根据每个病人的基因组成定制药物治疗来改变我们实践医学和提供医疗保健的方式。已经积累了大量的PGx数据，包括药物之间、基因之间、单核苷酸多态性（snp）之间的信息。规范化和整合的PGx信息有助于揭示药物治疗、基因组变异和表型性状之间的隐藏关系，从而更好地支持药物发现和下一代治疗。在这项研究中，我们通过整合来自多个知名PGx资源的癌症相关PGx信息，包括药物基因组学知识库（PharmGKB）、FDA药物标记中的PGx生物标志物和已发表的全基因组关联研究目录（GWAS），生成了一个标准化的、科学证据支持的基于癌症的PGx网络（CPN）。通过进行两个案例研究，我们成功地证明了CPN在药物再利用方面的能力。本研究建立的CPN提供了全面的基于癌症的PGx信息，以支持癌症导向的研究，特别是药物再利用。
Pharmacogenomics (PGx) as an emerging field, is poised to change the way we practice medicine and deliver health care by customizing drug therapies on the basis of each patient’s genetic makeup. A large volume of PGx data including information among drugs, genes, and single nucleotide polymorphisms (SNPs) has been accumulated. Normalized and integrated PGx information could facilitate revelation of hidden relationships among drug treatments, genomic variations, and phenotype traits to better support drug discovery and next generation of treatment. In this study, we generated a normalized and scientific evidence supported cancer based PGx network (CPN) by integrating cancer related PGx information from multiple well-known PGx resources including the Pharmacogenomics Knowledge Base (PharmGKB), the FDA PGx Biomarkers in Drug Labeling, and the Catalog of Published Genome-Wide Association Studies (GWAS). We successfully demonstrated the capability of the CPN for drug repurposing by conducting two case studies. The CPN established in this study offers comprehensive cancer based PGx information to support cancer orientated research, especially for drug repurposing.
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影响因子：
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作者：
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