A rADAR defense against RNAi.
A rADAR defense against RNAi.
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DOI：
10.1101/gad.313049.118
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发表时间：
2018-02-01
影响因子：
10.5
通讯作者：
Pasquinelli AE
中科院分区：
文献类型：
--
作者：
Pasquinelli AE
This Outlook by Pasquinelli discusses the study by Reich et al. in this issue of Genes & Development. They demonstrate that in C. elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Editing of cellular dsRNA by adenosine deaminases that act on RNA (ADARs) helps prevent host RNA silencing and inadvertent antiviral activity. Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271–282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity.
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影响因子：
4.1
作者：
Bajad P;Jantsch MF;Keegan L;O'Connell M
通讯作者：
O'Connell M
影响因子：
7.7
作者：
Deffit SN;Yee BA;Manning AC;Rajendren S;Vadlamani P;Wheeler EC;Domissy A;Washburn MC;Yeo GW;Hundley HA
通讯作者：
Hundley HA
影响因子：
7
作者：
Goldstein B;Agranat-Tamir L;Light D;Ben-Naim Zgayer O;Fishman A;Lamm AT
通讯作者：
Lamm AT
影响因子：
10.5
作者：
Reich DP;Tyc KM;Bass BL
通讯作者：
Bass BL
DOI：
10.1895/wormbook.1.170.1
发表时间：
2014-05-07
期刊：
WormBook : the online review of C. elegans biology
影响因子：
--
作者：
Billi, Allison C;Fischer, Sylvia E J;Kim, John K
通讯作者：
Kim, John K