Changes in Some Myelin Protein Markers and in Cytoskeletal Components During Wallerian Degeneration of Mouse Sciatic Nerve
Changes in Some Myelin Protein Markers and in Cytoskeletal Components During Wallerian Degeneration of Mouse Sciatic Nerve
复制标题
小鼠坐骨神经沃勒变性过程中部分髓鞘蛋白标志物和细胞骨架成分的变化
DOI：
10.1111/j.1471-4159.1986.tb13029.x
复制
发表时间：
1986
影响因子：
4.7
通讯作者：
J. Bourre
中科院分区：
文献类型：
--
作者：
B. Néchaud;M. Gumpel;J. Bourre
摘要：小鼠坐骨神经横断后，发生在远端变性段的事件序列，随后由相关的细胞骨架成分和髓鞘蛋白标记物的生化变化。中间丝和微管的成分经历早期变化。在3天内，神经丝三联体和外周蛋白消失，而许多肽携带的抗原决定簇共同的所有类别的中间丝积累。其中一些在1个月后仍然存在。微管蛋白模式的变化从高水平的微异质性-主要反映轴突的贡献-以较低的水平显示的主要雪旺细胞。还观察到髓磷脂标志物的量减少。然而，一个月后横断，免疫反应性碱性蛋白仍然存在于退化节段匀浆。
Abstract: After transection of the mouse sciatic nerve, the sequence of events occurring in the distal degenerating segment was followed by the biochemical changes related to the cytoskeletal components and to the myelin protein markers. The components of the intermediate filaments and of the microtubules undergo early changes. Within 3 days, the neurofilament triplet and the peripherin disappear whereas many peptides bearing the antigenic determinant common to all classes of intermediate filaments accumulate. Several of them persist after 1 month. The tubulin pattern changes from a high level of microheterogeneity—reflecting mostly the axonal contribution—to a lower level displayed by the predominant Schwann cells. A decrease in the amount of the myelin markers is also observed. However, a month after transection, immunoreactive basic protein is still present in the degenerated segment homogenate.
在没有髓磷脂组装的情况下，雪旺细胞表达主要髓磷脂糖蛋白。
DOI：
10.1073/pnas.81.6.1864
发表时间：
1984
影响因子：
11.1
作者：
Poduslo,JF;Berg,CT;Dyck,PJ
通讯作者：
Dyck,PJ