MDPV self-administration in female rats: influence of reinforcement history.
MDPV self-administration in female rats: influence of reinforcement history.
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雌性大鼠的MDPV自我给药：强化史的影响。
DOI：
10.1007/s00213-020-05726-2
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发表时间：
2021-03
影响因子：
3.4
通讯作者：
Collins GT
中科院分区：
文献类型：
--
作者：
Doyle MR;Sulima A;Rice KC;Collins GT
自行施用 3,4-亚甲二氧基吡咯戊酮 (MDPV) 的雄性大鼠子集的药物摄入量异常高；然而，影响这种行为的因素（例如强化历史和性别）尚不清楚。表征 MDPV 在雌性大鼠中的增强效力和有效性，以确定是否：1) 雌性大鼠的子集也发展出高水平的 MDPV 自我给药（即高反应表型）； 2）高反应者表型受各种强化历史（即对可卡因或食物的反应）影响的程度。雌性 Sprague Dawley 大鼠最初在固定比例 (FR) 1 和 FR5 强化方案下对 MDPV（0.032 mg/kg/输注）、可卡因（0.32 mg/kg/输注）或食物（45 mg 颗粒）有反应。 20 次治疗后，有可卡因和食物史的老鼠在另外 20 次治疗中对 MDPV 产生反应。 MDPV 的剂量反应曲线是在 FR5 和渐进比率 (PR) 强化方案下生成的。对 MDPV 做出反应的一组大鼠摄入了高水平的 MDPV。对可卡因（而非食物）有反应的历史抑制了高水平 MDPV 摄入的发展。当 MDPV 在 FR5（而非 PR）强化计划下可用时，自我给药水平存在很大的个体差异。 MDPV 在雌性大鼠中发挥着强大的强化作用，正如之前在雄性大鼠中所报道的那样。受试者之间 MDPV 自我给药的显着差异可能与人类吸毒行为的个体差异有关。
A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. Characterize the reinforcing potency and effectiveness of MDPV in female rats to determine whether: 1) a subset of females also develop high levels of MDPV self-administration (i.e., a high-responder phenotype); and 2) the degree to which the high-responder phenotype is influenced by various reinforcement histories (i.e., responding for cocaine or food). Female Sprague Dawley rats initially responded for MDPV (0.032 mg/kg/infusion), cocaine (0.32 mg/kg/infusion), or food (45-mg grain pellet) under fixed ratio (FR) 1 and FR5 schedules of reinforcement. After 20 sessions, the cocaine- and food-history rats responded for MDPV for 20 additional sessions. Dose-response curves for MDPV were generated under FR5 and progressive ratio (PR) schedules of reinforcement. A subset of rats responding for MDPV developed high levels of MDPV intake. A history of responding for cocaine, but not food, inhibited the development of high levels of MDPV intake. Large individual differences were observed in the level of self-administration when MDPV was available under an FR5, but not PR, schedule of reinforcement. MDPV functions as a powerful reinforcer in female rats, as has been previously reported in male rats. The substantial variability in MDPV self-administration between subjects may be related to individual differences in human drug-taking behavior.
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影响因子：
7.6
作者：
Gannon, Brenda M.;Baumann, Michael H.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
3.4
作者：
Lynch, Wendy J.
通讯作者：
Lynch, Wendy J.
影响因子：
4.2
作者：
DeVito, Elise E.;Babuscio, Theresa A.;Carroll, Kathleen M.
通讯作者：
Carroll, Kathleen M.
影响因子：
2.8
作者：
Johnson, Patrick S.;Johnson, Matthew W.
通讯作者：
Johnson, Matthew W.
影响因子：
4.2
作者：
Hernandez-Avila, CA;Rounsaville, BJ;Kranzler, HR
通讯作者：
Kranzler, HR