The surface-connected canalicular system in the sinus endothelial cells of rat spleen
The surface-connected canalicular system in the sinus endothelial cells of rat spleen
复制标题
大鼠脾窦内皮细胞表面连接的小管系统
DOI：
10.1007/s004410051304
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发表时间：
1999
影响因子：
3.6
通讯作者：
M. Miyoshi
中科院分区：
文献类型：
--
作者：
K. Uehara;M. Miyoshi
用硝酸镧作为细胞外间隙的示踪剂，用透射电子显微镜观察了大鼠脾窦内皮细胞内存在表面连接的小管系统。 结果表明，大鼠脾窦内皮细胞存在表面连通的小管系统。此外，通过计算机辅助重建显示了小管的三维排列。窦内皮细胞表面连接的小管系统由细长的小管组成，这些小管分叉、吻合，与质膜呈连续性。它们在细胞器之间来回缠绕，通常与质膜的球形内陷紧密相对，并与它们并排运行。未被硝酸镧渗透的小管以电子透明小管的形式存在，并伴有许多球状的质膜内陷。通过计算机辅助重建，从质膜的不同位置凹陷的小管被发现彼此连续，并穿透到窦内皮细胞的表面；它们也分支和吻合，在细胞质中形成一个复杂的网络。尽管血小板和血小板表面连接的小管系统被认为是颗粒排出和异物摄取的主要途径，也参与了钙的储存和运输，但目前尚不清楚脾窦内皮细胞表面连接的小管系统网络是否具有生理意义。
Abstract The existence of a surface-connected canalicular system in the splenic sinus endothelial cells of the rat has been demonstrated by transmission electron microscopy with lanthanum nitrate acting as a tracer for the extracellular space. In addition, the three-dimensional arrangement of the canaliculi has been revealed by computer-aided reconstruction. The surface-connected canalicular system of the sinus endothelial cells consists of slender canaliculi that are branched, anastomosed, and that show continuity with the plasma membrane. They twist in and out among the organelles and are often found in close apposition to the spherical invaginations of the plasma membrane and run alongside them. Canaliculi which are not infiltrated by lanthanum nitrate take the form of electron-lucent tubules and are accompanied by numerous spherical invaginations of the plasma membrane. From a computer-aided reconstruction, the canaliculi, which invaginate from various sites of the plasma membrane, have been found to be continuous with each other and to penetrate to the surface of the sinus endothelial cell; they also branch and anastomose to form a complex network in the cytoplasm. Although the surface-connected canalicular system in blood platelets and thrombocytes is believed to function as the main route for the discharge of granules and the uptake of foreign materials and also to take part in the storage and transport of calcium, it is unclear at present whether the network of the surface-connected canalicular system in splenic sinus endothelial cells has any physiological significance.
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影响因子：
4.3
作者：
John B. Sharefkin;Scott L. Diamond;S. Eskin;L. McIntire;Carl W. Dieffenbach
通讯作者：
John B. Sharefkin;Scott L. Diamond;S. Eskin;L. McIntire;Carl W. Dieffenbach
兰尼碱受体在平滑肌中的定位。
影响因子：
20.1
作者：
Lesh,RE;Nixon,GF;Fleischer,S;Airey,JA;Somlyo,AP;Somlyo,AV
通讯作者：
Somlyo,AV
人脾窦内衬细胞表达与单核细胞、巨噬细胞、内皮细胞和 T 淋巴细胞相关的抗原。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Buckley,PJ;Dickson,SA;Walker,WS
通讯作者：
Walker,WS
影响因子：
56.9
作者：
FRANGOS, JA;ESKIN, SG;IVES, CL
通讯作者：
IVES, CL