Cancer-Specific Mortality in Asian American Women Diagnosed with Gynecologic Cancer: A Nationwide Population-Based Analysis.
Cancer-Specific Mortality in Asian American Women Diagnosed with Gynecologic Cancer: A Nationwide Population-Based Analysis.
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亚裔美国妇女的癌症特异性死亡率被诊断出患有妇科癌症：基于人群的全国性分析。
DOI：
10.1158/1055-9965.epi-21-0829
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发表时间：
2022-03-01
期刊：
影响因子：
--
通讯作者：
Genkinger JM
中科院分区：
文献类型：
--
作者：
Karia PS;Tehranifar P;Visvanathan K;Wright JD;Genkinger JM
癌症是亚裔美国人（AA）死亡的主要原因，这是美国增长最快的人口群体。尽管不同种族的社会经济地位和健康行为存在异质性，但很少有研究评估AA种族人群的癌症结局。我们研究了AA种族和非西班牙裔白人（NHW）之间妇科癌症死亡率的差异。使用监测，流行病学和最终结果数据库，我们确定了1991-2016年诊断的卵巢癌（n= 69，113），子宫癌（n= 157，340）和宫颈癌病例（n= 41，460）。采用竞争风险回归，以NHW作为参考人群，按种族比较AA的癌症特异性死亡率。在校正分析中，AA具有较低的卵巢癌风险，（风险比[HR]：0.90，95% CI：0.86-0.94）和宫颈癌死亡（HR：0.80，95% CI：0.75-0.87），诊断时年龄≥50岁的患者之间的相关性更强（HRovary：0.87，95% CI：0.82-0.92; HR宫颈：0.74，95% CI：0.67-0.81）。子宫癌死亡率无总体差异（HR：1.03，95% CI：0.97-1.10）;然而，诊断时年龄<50岁的AA患者的子宫癌死亡风险高于NHW（HR：1.26，95% CI：1.08-1.46）。癌症死亡率模式各不相同，菲律宾和中国妇女子宫癌死亡风险最高，印度/巴基斯坦妇女卵巢癌和宫颈癌死亡风险最低。AA和NHWs之间的妇科癌症死亡率存在显著差异，AA种族具有异质性。需要对AA进行分类分析，以更好地了解妇科癌症的负担，并确定癌症预防工作的高危人群。
Cancer is the leading cause of death in Asian Americans (AA), the fastest-growing U.S. population group. Despite heterogeneity in socioeconomic status and health behaviors by ethnicity, few studies have assessed cancer outcomes across AA ethnic groups. We examined differences in gynecologic cancer mortality between AA ethnic groups and non-Hispanic Whites (NHW). Using the Surveillance, Epidemiology, and End Results database, we identified ovarian (n=69,113), uterine (n=157,340), and cervical cancer cases (n=41,460) diagnosed from 1991–2016. Competing risk regression was used to compare cancer-specific mortality for AAs by ethnicity, using NHW as the reference population. In adjusted analyses, AAs had a lower risk of ovarian (hazard ratio [HR]: 0.90, 95% CI: 0.86–0.94) and cervical cancer death (HR: 0.80, 95% CI: 0.75–0.87) than NHWs, with stronger associations among those ≥50 years at diagnosis (HRovary: 0.87, 95% CI: 0.82–0.92; HRcervix: 0.74, 95% CI: 0.67–0.81). No overall difference was noted for uterine cancer death (HR: 1.03, 95% CI: 0.97–1.10); however, AAs <50 years at diagnosis had a higher risk of uterine cancer death than NHWs (HR: 1.26, 95% CI: 1.08–1.46). Patterns of cancer mortality were heterogeneous, with Filipino and Chinese women at the highest risk of uterine cancer death and Indian/Pakistani women at the lowest risk of ovarian and cervical cancer death. There are significant differences in gynecologic cancer mortality between AAs and NHWs, with heterogeneity by AA ethnicity. Disaggregated analysis of AA is needed to better understand the burden of gynecologic cancer and identify high-risk groups for cancer prevention efforts.
生活方式因素、筛查测试的使用和临床病理特征与亚裔美国人结直肠癌生存相关的比较分析
影响因子：
8.8
作者：
Yi, M.;Xu, J.;Liu, P.;Chang, G. J.;Du, X. L.;Hu, C-y;Song, Y.;He, J.;Ren, Y.;Wei, Y.;Yang, J.;Hunt, K. K.;Li, X.
通讯作者：
Li, X.