miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!

miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!
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DOI:
10.1016/j.cmet.2013.04.004
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发表时间:
2013-05-07
期刊:
影响因子:
29
通讯作者:
Dorn GW 2nd
Dorn GW 2nd
中科院分区:
生物学1区
文献类型:
--
作者:
Dorn GW 2nd

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“Middle age ends and senescence begins, the day your descendants outnumber your friends.” “It’s not the years, Honey, it’s the mileage.” Indiana Jones from Raiders of the Lost Ark. The search for eternal youth is as old as mankind. In a recent Nature paper, Boon et al find that miR34 and its mRNA target PNUTS mediate DNA damage repair and provoke cardiac senescence. Interrupting the miR-34a/PNUTS pathway promises to favorably modify age- and stress-induced cardiac degeneration[AG1].
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