Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer.
Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer.
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DOI：
10.1002/cncr.26403
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发表时间：
2012-04-01
期刊：
影响因子：
6.2
通讯作者：
Rosen MP
中科院分区：
文献类型：
--
作者：
Letourneau JM;Ebbel EE;Katz PP;Oktay KH;McCulloch CE;Ai WZ;Chien AJ;Melisko ME;Cedars MI;Rosen MP
我们试图描述化疗后不孕症和提前绝经对育龄癌症女性的年龄特异性影响。 1041 名年龄在 18 岁至 40 岁之间被诊断患有癌症的女性接受了生殖健康史回顾性调查。包括五种癌症类型：白血病、霍奇金病（HD）、非霍奇金淋巴瘤（NHL）、乳腺癌和胃肠道癌（GI）。调查问题涉及：AOF（治疗后月经停止）、提前绝经（45 岁之前绝经）和不孕症（受孕失败）。使用逻辑回归根据诊断时的年龄确定 AOF 和不孕症的比例。使用截尾数据方法来确定提前绝经的可能性。 620 名女性仅接受化疗。对于 HD、NHL、乳腺癌和 GI，报告 AOF 的百分比分别为 8%、10%、9% 和 5%。 AOF 随着诊断时年龄的增加而显着增加 (p<0.05)。如果不是 AOF，35 岁时不孕的发生率至少为 40%，并且随着 HD 和乳腺癌诊断时年龄的增加而显着增加 (p<0.05)。 30 岁时，估计提前绝经的概率至少为 25%，并且随着 HD、NHL 和 GI 诊断时年龄的减小而显着增加 (p<0.05)。为了给患者提供适当的咨询，重要的是让他们了解除了急性卵巢功能衰竭之外，不孕和提前绝经的潜在风险增加。这些发现可以为被诊断患有癌症的年轻女性提供有关生殖障碍的改进的、针对特定年龄的咨询。
We sought to describe the age-specific impact of infertility and early menopause after chemotherapy, among reproductive age women with cancer. 1041 women diagnosed with cancer between the ages of 18 and 40 responded to retrospective survey on reproductive health history. Five cancer types were included: leukemia, Hodgkin’s disease (HD), non-Hodgkin lymphoma (NHL), breast cancer, and gastrointestinal cancer (GI). Survey questions addressed: AOF (cessation of menses after treatment), early menopause (menopause prior to 45 years old) and infertility (failed conception). Logistic regression was used to determine the proportions of AOF and infertility based on age at diagnosis. Censored data methods were used to determine the probability of early menopause. 620 women received chemotherapy alone. The percentage reporting AOF was 8%, 10%, 9%, and 5% for HD, NHL, breast cancer, and GI, respectively. AOF increased significantly with age at diagnosis (p<0.05). If not in AOF, the incidence of infertility was at least 40% at age 35 and increased significantly with age at diagnosis in HD and breast cancer (p<0.05). The estimated probability of early menopause was at least 25% at age 30 and increased significantly with younger age at diagnosis in HD, NHL, and GI (p<0.05). In order to give patients appropriate counseling, it is important that they understand the potential increased risk of infertility and early menopause beyond that of acute ovarian failure. These findings can provide improved, age-specific counseling regarding reproductive impairment for young women diagnosed with cancer.
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影响因子：
6.7
作者：
Stephen, Elizabeth Hervey;Chandra, Anjani
通讯作者：
Chandra, Anjani
影响因子：
45.3
作者：
Cvancarova, Milada;Samuelsen, Sven Ove;Fossa, Sophie Dorothea
通讯作者：
Fossa, Sophie Dorothea
影响因子：
3.2
作者：
Schover, Leslie R.
通讯作者：
Schover, Leslie R.
影响因子：
6.2
作者：
Sukumvanich, Paniti;Case, L. Doug;Naughton, Michelle J.
通讯作者：
Naughton, Michelle J.
DOI：
10.1016/0277-5379(85)90088-4
发表时间：
1985-01-01
期刊：
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY
影响因子：
--
作者：
VIVIANI, S;SANTORO, A;BONADONNA, G
通讯作者：
BONADONNA, G