The Emergence of Neisseria gonorrhoeae With Decreased Susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000
The Emergence of Neisseria gonorrhoeae With Decreased Susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000
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1999 年至 2000 年密苏里州堪萨斯城出现对阿奇霉素敏感性降低的淋病奈瑟菌
DOI：
10.1097/01.olq.0000109514.91508.fc
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发表时间：
2004
影响因子：
3.1
通讯作者：
W. Levine
中科院分区：
文献类型：
--
作者：
Catherine A McLean;S. Wang;G. Hoff;L. Dennis;D. Trees;J. Knapp;L. Markowitz;W. Levine
背景和目的我们描述了美国第一批对阿奇霉素（AziDS;最小抑菌浓度≥1.0 g/mL）敏感性降低的淋病奈瑟菌感染者。目的本研究的目的是确定AziDS N的风险因素。淋病和描述分离的微生物学。研究设计AziDS N患者。1999年通过淋球菌分离株监测项目（GISP）和2000年1月至2001年6月的扩大监测，在密苏里州的堪萨斯城发现了10例淋病。对1999名GISP参与者进行了病例对照研究，对照组为阿奇霉素敏感的N。淋病结果33例AziDS N.淋病被发现。病例组患者的年龄大于对照组患者（中位年龄，33岁对23岁; P <0.001）。50%的病例组和13%的对照组有与女性商业性工作者发生性关系的历史（比值比，7.0; 95%置信区间，1.3-36.0）; 50%的病例组和4%的对照组在A街遇到性伴侣（P <0.01）。AziDS N.淋病分离株的表型和基因型相似，并含有mtrR基因突变。结论：由于剩下的治疗选择很少，监测耐药的N。淋病越来越重要，特别是在高危人群中。
Background and Objectives We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin (AziDS; minimum inhibitory concentration ≥1.0 &mgr;g/mL) in the United States. Goal The goal of this study was to identify risk factors for AziDS N. gonorrhoeae and to describe isolate microbiology. Study Design Persons with AziDS N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project (GISP) in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 GISP participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. Results Thirty-three persons with AziDS N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P <0.001). Fifty percent of cases and 13% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95% confidence interval, 1.3–36.0); 50% of cases and 4% of control subjects met sex partners on street A (P <0.01). AziDS N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an mtrR gene mutation. Conclusions With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.
使用淋球菌外膜蛋白 I 的单克隆抗体对淋病奈瑟菌进行血清学分类。
DOI：
10.1093/infdis/150.1.44
发表时间：
1984
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Knapp,JS;Tam,MR;Nowinski,RC;Holmes,KK;Sandström,EG
通讯作者：
Sandström,EG