An insertional polymorphism of the proopiomelanocortin gene is associated with fasting insulin levels in childhood obesity.
An insertional polymorphism of the proopiomelanocortin gene is associated with fasting insulin levels in childhood obesity.
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阿黑皮质素原基因的插入多态性与儿童肥胖症的空腹胰岛素水平相关。
DOI：
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发表时间：
2004
影响因子：
5.8
通讯作者：
L. Perrone
中科院分区：
文献类型：
--
作者：
N. Santoro;E. D. del Giudice;G. Cirillo;P. Raimondo;I. Corsi;A. Amato;A. Grandone;L. Perrone
一系列的证据表明黑皮质素能系统在肥胖受试者的葡萄糖代谢调节中的作用。本研究的目的是探讨阿黑皮素原（POMC）对早发性肥胖患者胰岛素水平变异性的影响。为了解决这个问题，使用9 bp的插入多态性，AGC AGC GGC，POMC基因的核苷酸6979和6998之间的关联研究，在380（185名女孩）意大利肥胖儿童和青少年。等位基因频率在我们的患者（0.053）和300名地中海血统的瘦对照（0.045）中相当。有趣的是，我们发现，在肥胖患者中，这种多态性与空腹胰岛素水平的差异有关;在校正年龄、性别和青春期阶段后，这一发现仍然存在。杂合子的平均胰岛素水平比野生型等位基因纯合子高24%，并且胰岛素与体重指数之间存在更强的相关性（P < 0.001）。这些发现支持了黑皮质素途径可能调节肥胖受试者的葡萄糖代谢的假设，并表明这种常见的POMC变异可能参与了青春期后期和成年期多基因肥胖的自然史，有助于2型糖尿病和肥胖之间的联系。
Lines of evidence show a role of the melanocortinergic system in the regulation of glucose metabolism in obese subjects. The aim of this study was to investigate the influence of proopiomelanocortin (POMC) in the variability of insulin levels in early-onset obesity. To address this issue, an association study using a 9-bp insertional polymorphism, AGC AGC GGC, between nucleotides 6979 and 6998 of the POMC gene, was performed in 380 (185 girls) Italian obese children and adolescents. Allelic frequencies were comparable in our patients (0.053) and in 300 lean controls of Mediterranean descent (0.045). Interestingly, we showed that this polymorphism, in the obese patients, was associated with differences in fasting insulin levels; this finding persisted after correction for age, sex, and pubertal stage. Heterozygotes had 24% higher mean insulin levels than those homozygous for the wild allele and showed a stronger correlation between insulin and body mass index (P < 0.001). These findings support the hypothesis that the melanocortin pathway may modulate glucose metabolism in obese subjects and suggest that this common POMC variant may be involved in the natural history of polygenic obesity in late adolescence and adulthood, contributing to the link between type 2 diabetes and obesity.
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影响因子：
158.5
作者：
STUNKARD, AJ;HARRIS, JR;MCCLEARN, GE
通讯作者：
MCCLEARN, GE
DOI：
10.1210/jcem.84.9.5951
发表时间：
1999-09
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
J. Hixson;L. Almasy;Shelley A. Cole;S. Birnbaum;B. D. Mitchell;M. Mahaney;M. P. Stern;J. Maccluer;J. Blangero;A. Comuzzie
通讯作者：
J. Hixson;L. Almasy;Shelley A. Cole;S. Birnbaum;B. D. Mitchell;M. Mahaney;M. P. Stern;J. Maccluer;J. Blangero;A. Comuzzie
影响因子：
7.7
作者：
Rotimi, CN;Comuzzie, AG;Cooper, RS
通讯作者：
Cooper, RS
影响因子：
158.5
作者：
Sinha, R;Fisch, G;Caprio, S
通讯作者：
Caprio, S