Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction.
Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction.
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表现为类白血病反应的炎症性恶性纤维组织细胞瘤中的细胞因子。
DOI：
10.1182/blood.v82.7.2038.2038
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发表时间：
1993
期刊：
影响因子：
20.3
通讯作者：
Raymond A. Koski
中科院分区：
文献类型：
--
作者：
Mona F. Melhem;Arnold;Meisler;Reisuke Saito;Gene G. Finley;Helen R. Hockman;Raymond A. Koski
炎性恶性纤维组织细胞瘤（IMFH）是一种罕见的肿瘤，常伴有白细胞增多。在极少数情况下，类白血病反应归因于肿瘤产生的不明造血因子。在这项研究中，我们使用免疫组织化学技术显示细胞因子的免疫反应性的恶性细胞的两例IMFH表现为白血病样反应，并比较它们与两个恶性纤维组织细胞瘤，非炎症型。所有四个肿瘤的干细胞因子（SCF）、粒细胞集落刺激因子（G-CSF）、白细胞介素-2（IL-2）、IL-4、IL-5、干扰素-α（IFN-α）和胰岛素样生长因子-I均染色阳性。仅在两种IMFH中检测到的其他细胞因子包括IL-6、IL-7、IL-8、IFN-γ和角质形成细胞生长因子。粒细胞-巨噬细胞-CSF、IL-3和转化生长因子-β染色存在于两个IMFH肿瘤中的一个中，而不存在于非炎性肿瘤中。免疫组织化学染色定位于恶性细胞，表明与其单核细胞/组织细胞来源一致的失调的细胞因子表达。IMFH中某些细胞因子的表达可能是局部炎性浸润、肿瘤纤维化和恶性细胞侵袭性的原因。我们还检测到一个或两个IMFH患者的SCF，G-CSF，IL-6和肿瘤坏死因子的血清水平升高。后一种观察结果可能解释了在两例患者中观察到的骨髓细胞过多和其他副肿瘤症状，包括发热、不适和体重减轻。两种IMFH肿瘤中存在的不同细胞因子似乎是导致一例病例中观察到的嗜酸性粒细胞白血病反应和另一例患者中观察到的粒细胞白血病反应的原因。它们还可能负责肿瘤细胞群的扩增、成纤维细胞增殖和细胞外胶原蛋白的分泌增强。
Inflammatory malignant fibrous histiocytomas (IMFH) are rare tumors and are frequently associated with leukocytosis. In rare cases, leukemoid reactions were attributed to tumor production of unidentified hematopoietic factors. In this study, we used immunohistochemical techniques to show cytokine immunoreactivity in the malignant cells of two cases of IMFH presenting with leukemoid reactions and compared them with two malignant fibrous histocytomas, noninflammatory type. All four tumors stained positively for stem cell factor (SCF), granulocyte colony-stimulating factor (G-CSF), interleukin-2 (IL-2), IL-4, IL-5, interferon-alpha (IFN-alpha), and insulin-like growth factor-I. Other cytokines detected only in the two IMFH included IL-6, IL-7, IL-8, IFN-gamma, and keratinocyte growth factor. Granulocyte-macrophage-CSF, IL-3, and transforming growth factor-beta staining was present in one of the two IMFH tumors and was not present in the noninflammatory tumors. The immunohistochemical staining was localized to the malignant cells, suggesting deregulated cytokine expression consistent with their monocytic/histocytic origin. Expression of certain cytokines in the IMFH may account for the local inflammatory infiltrate, tumor fibrosis, and the aggressive nature of the malignant cells. We also detected elevated serum levels of SCF, G-CSF, IL-6, and tumor necrosis factor in one or both of the IMFH patients. These latter observations may explain the bone marrow hypercellularity and other paraneoplastic symptoms, including fever, malaise, and weight loss, observed in both patients. Different cytokines present in the two IMFH tumors appear to be responsible for the eosinophilic leukemoid reaction observed in one case and for the granulocytic leukemoid reaction observed in the other patient. They may also be responsible for expansion of the tumor-cell population, fibroblast proliferation, and enhanced secretion of extracellular collagen.
调节粒细胞和单核细胞的产生和功能。
影响因子：
3.6
作者：
Cannistra,SA;Griffin,JD
通讯作者：
Griffin,JD
干细胞因子与粒细胞集落刺激因子 (CSF) 或粒细胞巨噬细胞 CSF 结合可协同增加体内粒细胞生成。
影响因子：
20.3
作者：
Ulich,TR;delCastillo,J;McNiece,IK;Yi,ES;Alzona,CP;Yin,SM;Zsebo,KM
通讯作者：
Zsebo,KM
影响因子：
20.3
作者：
G. Damia;K. Komschlies;C. Faltynek;F. Ruscetti;R. Wiltrout
通讯作者：
G. Damia;K. Komschlies;C. Faltynek;F. Ruscetti;R. Wiltrout