Evidence for genetic variation as a factor in maintaining health.
Evidence for genetic variation as a factor in maintaining health.
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遗传变异作为维持健康因素的证据。
DOI：
10.1093/ajcn/83.2.431s
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
G. Duff
中科院分区：
文献类型：
--
作者：
G. Duff
对于许多慢性疾病，遗传学的影响是微妙和复杂的，不符合简单的孟德尔遗传模式，如单基因疾病。遗传变异可以影响起始事件的倾向、临床疾病状态的进展和疾病的轨迹。遗传变异如何影响复杂疾病的一个例子是细胞因子的白细胞介素1家族。这种细胞因子家族在介导炎症中起关键作用，炎症是许多慢性疾病的核心组成部分，包括冠状动脉疾病和类风湿性关节炎。最近的研究已经确定了编码白细胞介素1家族重要成员的基因的调控DNA中的许多序列变异，并且这些变异与对炎症反应的差异效应相关。这些反过来又改变了一些炎症起作用的疾病的风险，并影响生理反应，如对运动的炎症反应。随着这种新的遗传知识的发展和推广，有可能在临床疾病确立之前的早期阶段，而不是在组织受到永久性损害之后，进行保健干预。
For many chronic diseases, the influence of genetics is subtle and complex and does not conform to simple Mendelian patterns of inheritance as is seen with single-gene disorders. Genetic variation can influence the propensity for the initiating event, the progression to a clinical disease state, and the trajectory of disease. One example of how genetic variations may affect complex diseases is provided by the interleukin 1 family of cytokines. This cytokine family plays a key role in mediating inflammation, which is a central component of many chronic diseases, including coronary artery disease and rheumatoid arthritis. Recent research has identified many sequence variations in the regulatory DNA of the genes coding for important members of the interleukin 1 family, and these variations are associated with differential effects on the inflammatory response. These in turn alter the risk of some diseases in which inflammation plays a role and also affect physiologic responses, such as the inflammatory response to exercise. As this new genetic knowledge is developed and extended, it may be possible to make health care interventions at an earlier stage, before clinical disease is established, rather than after tissues have been permanently damaged.
影响因子：
15.9
作者：
Arnush, M;Heitmeier, MR;Corbett, JA
通讯作者：
Corbett, JA
影响因子：
29.4
作者：
ISAACS, KL;SARTOR, RB;HASKILL, S
通讯作者：
HASKILL, S
类风湿性关节炎和骨关节炎滑膜中 IL-1 受体拮抗剂蛋白的产生和基因表达。
DOI：
--
发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Firestein,GS;Berger,AE;Tracey,DE;Chosay,JG;Chapman,DL;Paine,MM;Yu,C;Zvaifler,NJ
通讯作者：
Zvaifler,NJ