Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort.
Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort.
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DOI：
10.1093/schbul/sbad017
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发表时间：
2023-07-04
影响因子：
6.6
通讯作者：
Fisher HL
中科院分区：
文献类型：
--
作者：
Newbury JB;Arseneault L;Moffitt TE;Odgers CL;Howe LD;Bakolis I;Reuben A;Danese A;Sugden K;Williams B;Rasmussen LJH;Trotta A;Ambler AP;Fisher HL
暴露于社会环境逆境（例如，城市化，污染，邻里剥夺，犯罪和家庭劣势）的儿童更有可能在青春期发展为亚临床精神病经历（例如，幻听，偏执）。然而，这种情况发生的途径以前没有研究过。我们假设认知能力和炎症可以部分解释这种关联。 数据来自环境风险纵向双胞胎研究，一个队列的2232名儿童出生于1994-1995年在英格兰和威尔士，并跟踪到18岁。社会环境逆境从出生到10岁进行测量，并分为身体风险（定义为高城市化和空气污染）和社会经济风险（定义为高邻里剥夺，邻里混乱和家庭劣势）。在12岁时评估认知能力（总体、结晶、液体和工作记忆）;在18岁时测量血液样本中的炎症标志物（C反应蛋白、白细胞介素-6、可溶性尿激酶纤溶酶原激活物受体）。参与者在18岁时接受了关于精神病经历的采访。 较高的身体风险和社会经济风险与青少年精神病经历的几率增加有关。最大的中介途径是通过整体认知能力和结晶能力的社会经济风险，分别占精神病经历相关性的~11%和~19%。在探索性（部分横断面）分析中，通过炎症标志物未发现具有统计学意义的通路。 认知能力，特别是结晶能力，可以部分解释儿童社会环境逆境和青少年精神病的经验之间的关联。支持生活在弱势环境中的儿童认知发展的干预措施可以缓冲他们对发展亚临床精神病现象。
Children exposed to socioenvironmental adversities (eg, urbanicity, pollution, neighborhood deprivation, crime, and family disadvantage) are more likely to subsequently develop subclinical psychotic experiences during adolescence (eg, hearing voices, paranoia). However, the pathways through which this occurs have not been previously investigated. We hypothesized that cognitive ability and inflammation would partly explain this association. Data were utilized from the Environmental-Risk Longitudinal Twin Study, a cohort of 2232 children born in 1994–1995 in England and Wales and followed to age 18. Socioenvironmental adversities were measured from birth to age 10 and classified into physical risk (defined by high urbanicity and air pollution) and socioeconomic risk (defined by high neighborhood deprivation, neighborhood disorder, and family disadvantage). Cognitive abilities (overall, crystallized, fluid, and working memory) were assessed at age 12; and inflammatory markers (C-reactive protein, interleukin-6, soluble urokinase plasminogen activator receptor) were measured at age 18 from blood samples. Participants were interviewed at age 18 regarding psychotic experiences. Higher physical risk and socioeconomic risk were associated with increased odds of psychotic experiences in adolescence. The largest mediation pathways were from socioeconomic risk via overall cognitive ability and crystallized ability, which accounted for ~11% and ~19% of the association with psychotic experiences, respectively. No statistically significant pathways were found via inflammatory markers in exploratory (partially cross-sectional) analyses. Cognitive ability, especially crystallized ability, may partly explain the association between childhood socioenvironmental adversity and adolescent psychotic experiences. Interventions to support cognitive development among children living in disadvantaged settings could buffer them against developing subclinical psychotic phenomena.
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影响因子：
25.8
作者：
Khandaker GM;Pearson RM;Zammit S;Lewis G;Jones PB
通讯作者：
Jones PB
影响因子：
7.9
作者：
de Prado Bert P;Mercader EMH;Pujol J;Sunyer J;Mortamais M
通讯作者：
Mortamais M
影响因子：
3.1
作者：
Deoni SC;O'Muircheartaigh J;Elison JT;Walker L;Doernberg E;Waskiewicz N;Dirks H;Piryatinsky I;Dean DC 3rd;Jumbe NL
通讯作者：
Jumbe NL
影响因子：
6.9
作者：
Dhossche, D;Ferdinand, R;Verhulst, F
通讯作者：
Verhulst, F
影响因子：
4.5
作者：
Khandaker, Golam M.;Barnett, Jennifer H.;White, Ian R.;Jones, Peter B.
通讯作者：
Jones, Peter B.