The Effects of Air Pollution on the Brain: a Review of Studies Interfacing Environmental Epidemiology and Neuroimaging.
The Effects of Air Pollution on the Brain: a Review of Studies Interfacing Environmental Epidemiology and Neuroimaging.
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DOI：
10.1007/s40572-018-0209-9
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发表时间：
2018-09
影响因子：
7.9
通讯作者：
Mortamais M
中科院分区：
文献类型：
--
作者：
de Prado Bert P;Mercader EMH;Pujol J;Sunyer J;Mortamais M
在过去的十年里，越来越多的证据引起了人们对吸入污染物对中枢神经系统潜在有害影响的关注。在一般人群中，与交通相关的空气污染（TRAP）暴露与儿童认知、行为和精神运动发育的不利影响有关，并与老年人认知能力下降和患痴呆症的高风险有关。近年来，研究人员将环境流行病学与磁共振成像相结合，研究TRAP在体内对人脑的影响。本系统综述的目的是描述和综合这些研究的结果。在PubMed中使用特定关键词进行文献检索。所选的研究表明，脑白质、皮质灰质和基底神经节可能是TRAP的靶点。检测到的脑损伤可能与认知变化有关。TRAP对认知的影响在生物学上似乎是合理的。将环境流行病学与神经影像学相结合是一个有待改进的新兴领域。未来的研究，结合实验结果的输入，应该提供更多相关和详细的知识，了解TRAP暴露与在普通人群中观察到的认知、行为和精神运动障碍之间关系的本质。
An emerging body of evidence has raised concern regarding the potentially harmful effects of inhaled pollutants on the central nervous system during the last decade. In the general population, traffic-related air pollution (TRAP) exposure has been associated with adverse effects on cognitive, behavior, and psychomotor development in children, and with cognitive decline and higher risk of dementia in the elderly. Recently, studies have interfaced environmental epidemiology with magnetic resonance imaging to investigate in vivo the effects of TRAP on the human brain. The aim of this systematic review was to describe and synthesize the findings from these studies. The bibliographic search was carried out in PubMed with ad hoc keywords. The selected studies revealed that cerebral white matter, cortical gray matter, and basal ganglia might be the targets of TRAP. The detected brain damages could be involved in cognition changes. The effect of TRAP on cognition appears to be biologically plausible. Interfacing environmental epidemiology and neuroimaging is an emerging field with room for improvement. Future studies, together with inputs from experimental findings, should provide more relevant and detailed knowledge about the nature of the relationship between TRAP exposure and cognitive, behavior, and psychomotor disorders observed in the general population.
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与低水平锰暴露有关的神经结局，在无症状焊接学员中。
DOI：
10.5271/sjweh.3466
发表时间：
2015-01
期刊：
Scandinavian journal of work, environment & health
影响因子：
--
作者：
Baker MG;Criswell SR;Racette BA;Simpson CD;Sheppard L;Checkoway H;Seixas NS
通讯作者：
Seixas NS
影响因子：
2.5
作者：
Calderon-Garciduenas, Lilian;Engle, Randall;D'Angiulli, Amedeo
通讯作者：
D'Angiulli, Amedeo
影响因子：
3.7
作者：
Dutta K;Ghosh D;Nazmi A;Kumawat KL;Basu A
通讯作者：
Basu A
影响因子：
15.9
作者：
Block, Michelle L.;Calderon-Garciduenas, Lilian
通讯作者：
Calderon-Garciduenas, Lilian
影响因子：
4.9
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
通讯作者：
Racette BA