Revisiting the Daily Timing of POS Phagocytosis.

Revisiting the Daily Timing of POS Phagocytosis.
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重新审视 POS 吞噬作用的每日计时。

DOI:
10.1007/978-3-031-27681-1_75
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发表时间:
2023
影响因子:
--
通讯作者:
Williams,DavidS
Williams,DavidS
中科院分区:
医学4区
文献类型:
--
作者:
Paniagua,AntonioE;Sabharwal,HarjasS;Kethu,Kausalya;Chang,AndrewW;Williams,DavidS

文献摘要

参考文献

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视网膜色素上皮(RPE)细胞每天摄取光感受器外节(POS)的尖端,吞噬体数量在24小时周期内变化。文献中的一个主要焦点是在光照后不久的吞噬体浓度的峰值。此外,这个峰值经常被推断为代表POS尖端摄入的峰值。在这里,我们回顾了有关RPE中吞噬体数量每日周期的新旧文献,并得出结论,吞噬体浓度峰值的时间变化比目前公认的要多。我们还讨论了吞噬体的数量是由吞噬体降解的速率以及摄取速率的影响,鉴于吞噬体的半衰期可能不是恒定的,在整个日常周期,最大的POS摄取可能不一定与吞噬体浓度的峰值相一致。
Retinal pigment epithelium (RPE) cells daily ingest the tips of the photoreceptor outer segments (POSs), with phagosome number varying throughout a 24-h cycle. A major focus in the literature has been on a peak in phagosome concentration shortly after lights-on. Moreover, this peak has frequently been inferred to represent a peak in POS tip ingestion. Here, we have reviewed old and new literature on the daily cycle of phagosome number in the RPE and conclude that there is more variation in the timing of phagosome concentration peaks than is currently acknowledged. We also discuss that phagosome quantity is affected by the rate of phagosome degradation as well as the rate of ingestion; given that phagosome half-life may not be constant throughout the daily cycle, maximal POS ingestion may not necessarily coincide with a peak in phagosome concentration.
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