Brain corticotropin-releasing factor (CRF) and catecholamine responses in acutely stressed rats.
Brain corticotropin-releasing factor (CRF) and catecholamine responses in acutely stressed rats.
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急性应激大鼠的脑促肾上腺皮质激素释放因子（CRF）和儿茶酚胺反应。
DOI：
10.1507/endocrj1954.32.709
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Z. Ota
中科院分区：
文献类型：
--
作者：
S. Suemaru;K. Hashimoto;Z. Ota
乙醚剖腹应激引起大鼠下丘脑CRF浓度迅速增加，随后迅速减少，随后增加。冷束缚应激15 min后显著降低下丘脑CRF浓度。血清ACTH和皮质酮水平显着升高，在15分钟后发病的两种压力。延髓的CRF反应与下丘脑的CRF反应不同。下丘脑中去甲肾上腺素浓度降低，而下丘脑和延髓中多巴胺浓度显著增加。在整个应激期间，这些组织中的肾上腺素浓度未显示出任何显著变化。结果表明：下丘脑CRF在急性应激刺激ACTH分泌中起主要作用，下丘脑CRF减少是由于应激早期过度释放所致，下丘脑CRF与延髓CRF受不同机制的控制，下丘脑去甲肾上腺素可能不参与应激早期刺激下丘脑CRF分泌的作用;并且在下丘脑和延髓中对儿茶酚胺的调节不同。
Ether-laparotomy stress produced a rapid increase in rat hypothalamic CRF concentration, followed by a rapid reduction and subsequent increase. Cold-restraint stress significantly reduced hypothalamic CRF concentration at 15 min after stress onset. Serum ACTH and corticosterone levels were significantly elevated at 15 min after the onset of both stresses. The CRF responses in the medulla oblongata were not similar to the hypothalamic CRF responses. Norepinephrine concentration in the hypothalamus was reduced, whereas dopamine concentration in the hypothalamus and medulla oblongata was significantly increased. Epinephrine concentrations in these tissues did not show any significant change throughout the stress period. The observations lead to the following conclusions: hypothalamic CRF plays a major role in stimulating ACTH secretion under acute stress; the reduction in hypothalamic CRF is due to an excess release in the early phase of acute stress; hypothalamic CRF and medulla oblongata CRF are controlled by different mechanisms; norepinephrine in the hypothalamus may not be involved in stimulating hypothalamic CRF secretion in the early phase of acute stress; and catecholamines are regulated differently in the hypothalamus and medulla oblongata.
神经递质和垂体功能：ACTH 分泌的调节。
DOI：
--
发表时间：
1980
期刊：
Federation proceedings
影响因子：
--
作者：
Ganong,WF
通讯作者：
Ganong,WF
合成绵羊促肾上腺皮质激素释放因子、糖皮质激素、儿茶酚胺、神经垂体肽和其他物质对培养促肾上腺皮质激素细胞的影响。
影响因子：
4.8
作者：
Vale,W;Vaughan,J;Smith,M;Yamamoto,G;Rivier,J;Rivier,C
通讯作者：
Rivier,C
DOI：
10.1073/pnas.80.15.4851
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
RIVIER, J;SPIESS, J;VALE, W
通讯作者：
VALE, W