Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers.
Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers.
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肿瘤相关巨噬细胞在妇科和乳腺癌的发生、发展和靶向治疗中的失调。
DOI：
10.1186/s13045-021-01198-9
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发表时间：
2021-10-30
影响因子：
28.5
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Xu T;Yu S;Zhang J;Wu S
妇科和乳腺癌是一组异质性恶性肿瘤。虽然现有的治疗策略改善了患者的临床结局，但晚期疾病的总生存率仍不令人满意。越来越多的证据表明，肿瘤的发生、发展和预后与肿瘤微环境（TME）密切相关，TME限制了免疫应答，促进了肿瘤的恶性进展。肿瘤相关巨噬细胞（Tumor-associated macrophages，TAMs）是TME的主要组成部分，在肿瘤转移、免疫抑制和治疗耐药中起着关键的调节作用。一些临床前试验研究了靶向TAM的潜在药物，以实现有效的抗癌治疗。本文就TAMs的各种功能及其如何通过调节癌细胞增殖、肿瘤血管生成和肿瘤相关免疫抑制来影响妇科和乳腺癌的发生发展作一综述。此外，我们还讨论了禁用TAMs信号作为癌症治疗策略的一部分的潜在应用，以及CAR巨噬细胞，基于TAMs的疫苗和TAMs纳米生物技术。这些研究进展支持靶向TAM与常规治疗相结合可能在未来用作妇科和乳腺癌的有效治疗方法。
Gynecological and breast cancers are a group of heterogeneous malignant tumors. Although existing treatment strategies have ameliorated the clinical outcomes of patients, the overall survival rate of advanced diseases remains unsatisfactory. Increasing evidence has indicated that the development and prognosis of tumors are closely related to the tumor microenvironment (TME), which restricts the immune response and provokes malignant progression. Tumor-associated macrophages (TAMs) are the main component of TME and act as a key regulator in tumor metastasis, immunosuppression and therapeutic resistance. Several preclinical trials have studied potential drugs that target TAMs to achieve potent anticancer therapy. This review focuses on the various functions of TAMs and how they influence the carcinogenesis of gynecological and breast cancers through regulating cancer cell proliferation, tumor angiogenesis and tumor-related immunosuppression. Besides, we also discuss the potential application of disabling TAMs signaling as a part of cancer therapeutic strategies, as well as CAR macrophages, TAMs-based vaccines and TAMs nanobiotechnology. These research advances support that targeting TAMs combined with conventional therapy might be used as effective therapeutics for gynecological and breast cancers in the future.
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