Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients.
Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients.
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MTDH和IL-10的表达是ER阴性或PR阴性乳腺癌患者预后较差的独立预测因子
DOI：
10.3390/jcm9103153
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发表时间：
2020-09-29
影响因子：
3.9
通讯作者：
Chiang EI
中科院分区：
文献类型：
--
作者：
Chu PY;Wang SM;Chen PM;Tang FY;Chiang EI
(1)背景：肿瘤缺氧可导致肿瘤转移和某些免疫反应，并干扰正常的生物学功能。它还影响葡萄糖摄入，下调氧化磷酸化，并抑制由缺氧诱导因子1α（HIF-1α）调节的脂肪酸去饱和。尽管研究发现肿瘤缺氧可促进肿瘤转移，但HIF-1α调控基因的作用及其临床应用尚未完全整合。(2)研究方法：我们通过网络界面使用基因表达谱交互分析（GEPIA）数据库检测HIF-1α、metadherin（MTDH）和白细胞介素（IL）-10 mRNA表达之间的相关性，以及它们在乳腺癌预后中的表达模式;使用免疫组织化学对组织微阵列（TMA）进行MTDH和IL-10蛋白表达染色。(3)结果：HIF-1α、MTDH、IL-10 mRNA表达与预后密切相关。乳腺癌患者MTDH和IL-10蛋白表达通常为雌激素受体（ER）或孕激素受体（PR）阴性，晚期肿瘤IL-10表达较高。对MTDH和IL-10蛋白表达状况进行单因素和多因素分析，结果显示MTDH和IL-10蛋白表达在ER阴性或PR阴性乳腺癌患者中预后较差。(4)结论：我们提出了一个新的见解，缺氧肿瘤的代谢和免疫证据，为乳腺癌的治疗。
(1) Background: Tumor hypoxia leads to metastasis and certain immune responses, and interferes with normal biological functions. It also affects glucose intake, down-regulates oxidative phosphorylation, and inhibits fatty-acid desaturation regulated by hypoxia-inducible factor 1α (HIF-1α). Although tumor hypoxia has been found to promote tumor metastasis, the roles of HIF-1α-regulated genes and their application are not completely integrated in clinical practice. (2) Methods: We examined the correlation between HIF-1α, metadherin (MTDH), and interleukin (IL)-10 mRNA expression, as well as their expression patterns in the prognosis of breast cancer using the Gene Expression Profiling Interactive Analysis (GEPIA) databases via a web interface; tissue microarrays (TMAs) were stained for MTDH and IL-10 protein expression using immunohistochemistry. (3) Results: HIF-1α, MTDH, and IL-10 mRNA expression are highly correlated and strongly associated with poor prognosis. MTDH and IL-10 protein expression of breast cancer patients usually harbored negative estrogen receptor (ER) or progesterone receptor (PR) status, and late-stage tumors have higher IL-10 expression. With regard to MTDH and IL-10 protein expression status for using univariate and multivariate analysis, the results showed that the protein expression of MTDH and IL-10 in ER-negative or PR-negative breast cancer patients have the worse prognosis. (4) Conclusions: we propose a new insight into hypoxia tumors in the metabolism and immune evidence for breast cancer therapy.
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影响因子：
3.8
作者：
Nechuta, Sarah;Lu, Wei;Zheng, Ying;Cai, Hui;Bao, Ping-Ping;Gu, Kai;Zheng, Wei;Shu, Xiao Ou
通讯作者：
Shu, Xiao Ou
影响因子：
--
作者：
Lee, Seok-Geun;Kang, Dong-Chul;DeSalle, Rob;Sarkar, Devanand;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
8.8
作者：
Aras S;Zaidi MR
通讯作者：
Zaidi MR
DOI：
10.2147/hp.s50269
发表时间：
2014
期刊：
Hypoxia (Auckland, N.Z.)
影响因子：
--
作者：
Harris AJ;Thompson AR;Whyte MK;Walmsley SR
通讯作者：
Walmsley SR