Biocompatible hydrogels by oxime Click chemistry.

Biocompatible hydrogels by oxime Click chemistry.
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DOI:
10.1021/bm301346e
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发表时间:
2012-10-08
期刊:
影响因子:
6.2
通讯作者:
Maynard, Heather D.
Maynard, Heather D.
中科院分区:
化学2区
文献类型:
--
作者:
Grover, Gregory N.;Lam, Jonathan;Nguyen, Thi H.;Segura, Tatiana;Maynard, Heather D.

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Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.
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