PD-L1 and gastric cancer prognosis: A systematic review and meta-analysis.
PD-L1 and gastric cancer prognosis: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0182692
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Gu L;Chen M;Guo D;Zhu H;Zhang W;Pan J;Zhong X;Li X;Qian H;Wang X
程序性细胞死亡配体1（PD-L1）在许多恶性肿瘤中表达，并与包括胃癌（GC）在内的预后不良相关。然而，PD-L1表达与胃癌预后的关系仍存在争议。本文旨在通过Meta分析探讨PD-L1表达与胃癌预后的关系。对于本研究，检索了以下数据库中2003年6月至2017年2月发表的文章：PubMed、EBSCO、Web of Science和科克伦图书馆。提取的基线信息包括：作者、发表年份、进行研究的国家、研究设计、样本量、随访时间、研究人群的基线特征、病理学数据、总生存期（OS）。根据规定的纳入和排除标准，共选择了15项符合条件的研究（涵盖3291例患者）进行荟萃分析。分析显示PD-L1表达水平与胃癌的总生存期相关（风险比，HR = 1.46，95%CI = 1.08-1.98，P = 0.01，随机效应）。除此之外，亚组分析显示，肿瘤浸润较深、淋巴结转移阳性、静脉浸润阳性、EB病毒感染阳性（EBV+）、微卫星不稳定（MSI）的胃癌患者更易表达PD-L1。这项荟萃分析的结果表明，GC患者，特别是EBV+和MSI，可能是PD-1导向治疗的主要候选人。这些发现支持抗PD-L1/PD-1抗体作为一种有希望用于GC的免疫疗法。
The expression of Programmed cell Death Ligand 1 (PD-L1) is observed in many malignant tumors and is associated with poor prognosis including Gastric Cancer (GC). The relationship between PD-L1 expression and prognosis, however, is controversial in GC. This paper purports to use a meta-analysis to investigate the relationship between PD-L1 expression and prognosis in GC. For this study, the following databases were searched for articles published from June 2003 until February 2017: PubMed, EBSCO, Web of Science and Cochrane Library. The baseline information extracted were: authors, year of publication, country where the study was performed, study design, sample size, follow-up time, baseline characteristics of the study population, pathologic data, overall survival (OS). A total of 15 eligible studies covering 3291 patients were selected for a meta-analysis based on specified inclusion and exclusion criteria. The analysis showed that the expression level of PD-L1 was associated with the overall survival in GC (Hazard Ratio, HR = 1.46, 95%CI = 1.08–1.98, P = 0.01, random-effect). In addition to the above, subgroup analysis showed that GC patients with deeper tumor infiltration, positive lymph-node metastasis, positive venous invasion, Epstein-Barr virus infection positive (EBV+), Microsatellite Instability (MSI) are more likely to expression PD-L1. The results of this meta-analysis suggest that GC patients, specifically EBV+ and MSI, may be prime candidates for PD-1 directed therapy. These findings support anti-PD-L1/PD-1 antibodies as a kind of immunotherapy which is promising for GC.
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影响因子：
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作者：
Chang H;Jung WY;Kang Y;Lee H;Kim A;Kim HK;Shin BK;Kim BH
通讯作者：
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影响因子：
15.8
作者：
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发表时间：
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期刊：
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影响因子：
3.8
作者：
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通讯作者：
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