Ascaris, atopy, and exercise-induced bronchoconstriction in rural and urban South African children.
Ascaris, atopy, and exercise-induced bronchoconstriction in rural and urban South African children.
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DOI：
10.1016/j.jaci.2009.09.010
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发表时间：
2010-01
影响因子：
14.2
通讯作者：
Burney, Peter
中科院分区：
文献类型：
--
作者：
Calvert, James;Burney, Peter
地方性寄生虫病人群IgE水平高，但过敏性疾病水平低。我们研究了寄生虫蛔虫感染与过敏性致敏和运动性支气管痉挛（EIB）之间的关系。我们试图研究蛔虫感染对支气管高反应性、皮肤试验和特异性IgE水平的影响。在南非城市和农村儿童中进行了一项横断面流行调查，以测量EIB水平。一组儿童样本被纳入了一项嵌套病例对照研究，以进一步调查他们对运动的反应。分析采用加权逻辑回归。蛔虫感染的受试者几何平均总IgE水平较高(感染的受试者：451 IU (95% CI, 356-572)，而未感染的受试者：344 IU (95% CI, 271-437), P 5.04)，高水平的总IgE水平与检测到的针对空气过敏原的特异性IgE呈正相关，但蛔虫感染与特异性IgE滴度之间没有显著关联。蛔虫感染与皮肤试验阳性反应的风险降低相关（优势比0.63;95% CI, 0.42-0.94; P < 0.05）。2003)，但EIB的风险增加（优势比，1.62;95% CI, 1.23-2.11; P < 0.05）。在寄生虫高流行的地区，蛔虫可能诱导肺部的炎症反应独立于其对IgE产生的影响。这可以解释在检查地蠕虫感染、特应性反应和哮喘之间关系的研究中看到的一些相互矛盾的发现。
Populations with endemic parasitosis have high levels of IgE but low levels of allergic disease. We investigated the association between infection with the parasite Ascaris allergic sensitization, and exercise-induced bronchospasm (EIB). We sought to investigate the effect of Ascaris infection on bronchial hyperreactivity, skin testing, and specific IgE levels. A cross-sectional prevalence survey was conducted in urban and rural South African children to measure levels of EIB. A sample of children was enrolled in a nested case-control study for further investigation based on response to exercise. Analyses used weighted logistic regression. Geometric mean total IgE levels were higher in Ascaris–infected subjects (infected subjects: 451 IU (95% CI, 356-572) vs uninfected subjects: 344 IU (95% CI, 271-437), P 5.04), and high levels of total IgE were positively associated with detection of specific IgE to the aeroallergens tested, but there was no significant association between Ascaris infection and titers of specific IgE. Ascaris infection was associated with a decreased risk of a positive skin test response (odds ratio, 0.63; 95% CI, 0.42–0.94; P 5 .03) but an increased risk of EIB (odds ratio, 1.62; 95% CI, 1.23-2.11; P 5 .001). In areas of high parasite endemicity, Ascaris might induce an inflammatory response in the lungs independent of its effect on IgE production. This could explain some of the contradictory findings seen in studies examining the association between geohelminth infection, atopy, and asthma.
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影响因子：
9.6
作者：
Arshad, SH;Kurukulaaratchy, RJ;Matthews, S
通讯作者：
Matthews, S
影响因子：
9.6
作者：
Mannino, DM;Homa, DM;Redd, SC
通讯作者：
Redd, SC
影响因子：
14.2
作者：
Calvert, J;Burney, P
通讯作者：
Burney, P
DOI：
10.1164/rccm.2107020
发表时间：
2002-06-01
影响因子：
24.7
作者：
Palmer, LJ;Celed贸n, JC;Xu, XP
通讯作者：
Xu, XP
影响因子：
24.3
作者：
Pereira, M. U.;Sly, P. D.;Stein, R. T.
通讯作者：
Stein, R. T.