Mechanosensitive channels in lung disease.
Mechanosensitive channels in lung disease.
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DOI：
10.3389/fphys.2023.1302631
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
机械敏感通道(MS通道)是一种膜蛋白，能够在外界机械刺激的动态范围内对机械应力做出反应。近年来，人们发现MS通道在细胞感知和反应细胞外力信号和细胞内力信号的过程中扮演着重要的哨兵角色。人们越来越认识到离子通道的机械激活及其随后启动的下游信号通路。瞬时受体电位(Trp)超家族成员和Piezo通道在人体组织中广泛表达，参与多种细胞功能。Trp和Piezo通道都被认为在包括肺在内的疾病状态的生理动态平衡和病理生理学中发挥关键作用。在这里，我们回顾了Trp和Piezo通道在成人肺中的表达、调节和功能的当前知识状况，在成人肺中，以及在诸如哮喘、COPD和肺纤维化等肺部疾病中，机械力可能在这些疾病的结构和功能变化中扮演不同的角色。了解肺中Trp和Piezo可以为肺部疾病的治疗提供新的靶点。
Mechanosensitive channels (MS channels) are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli. In recent years, it has been found that MS channels play an important role as “sentinels” in the process of cell sensing and response to extracellular and intracellular force signals. There is growing appreciation for mechanical activation of ion channels and their subsequent initiation of downstream signaling pathways. Members of the transient receptor potential (TRP) superfamily and Piezo channels are broadly expressed in human tissues and contribute to multiple cellular functions. Both TRP and Piezo channels are thought to play key roles in physiological homeostasis and pathophysiology of disease states including in the lung. Here, we review the current state of knowledge on the expression, regulation, and function of TRP and Piezo channels in the context of the adult lung across the age spectrum, and in lung diseases such as asthma, COPD and pulmonary fibrosis where mechanical forces likely play varied roles in the structural and functional changes characteristic of these diseases. Understanding of TRP and Piezo in the lung can provide insights into new targets for treatment of pulmonary disease.
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影响因子：
3.7
作者：
Chen, Qing-Zi;Zhou, Yu-Bo;Li, Jian-Hua
通讯作者：
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DOI：
10.1152/ajplung.00315.2009
发表时间：
2010-09-01
影响因子：
4.9
作者：
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通讯作者：
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影响因子：
10.7
作者：
Fang, Xiang-Zhi;Li, Min;Wang, Ya-Xin;Zhang, Pei;Sun, Miao-Miao;Xu, Jia-Xin;Yang, Yi-Yi;He, Ya-Jun;Yu, Yuan;Li, Rui-Ting;Zhou, Ting;Reng, Le-Hao;Sun, De-Yi;Shu, Hua-Qing;Yuan, Shi-Ying;Xu, Ji-Qian;Shang, You
通讯作者：
Shang, You
DOI：
10.1073/pnas.2023130118
发表时间：
2021-04-27
影响因子：
11.1
作者：
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通讯作者：
Sonkusare, Swapnil K.
影响因子：
4.5
作者：
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通讯作者：
Honore, Eric