Evaluation of the humoral immune response in mice orally vaccinated with live recombinant attenuated Salmonella enterica delivering a secreted form of Yersinia pestis PsaA.
Evaluation of the humoral immune response in mice orally vaccinated with live recombinant attenuated Salmonella enterica delivering a secreted form of Yersinia pestis PsaA.
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DOI：
10.1016/j.vaccine.2010.06.070
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发表时间：
2010-08-16
期刊：
影响因子：
5.5
通讯作者：
Curtiss, Roy, III
中科院分区：
文献类型：
--
作者：
Torres-Escobar, Ascencion;Juarez-Rodriguez, Maria Dolores;Branger, Christine G.;Curtiss, Roy, III
Yersinia pestis PsaA is an adhesin that is synthesized inside macrophages. Here, we evaluated the immune profile of codon-optimized Y. pestis PsaA synthesized in a live recombinant attenuated Salmonella vaccine (RASV) strain χ9558. Oral immunization of BALB/c mice with χ9558(pYA3705) delivering a secreted form of PsaA, elicited a systemic PsaA-specific immunoglobulin G (IgG) response but offered limited protection against lethal challenge with the intranasally introduced Y. pestis CO92 strain. Our results suggest that appropriate fine-tuning of Y. pestis PsaA delivery by RASV could improve its protective role in curtailing plague colonization and infection.
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影响因子：
3.1
作者：
HOPKINS, S;KRAEHENBUHL, JP;NARDELLIHAEFLIGER, D
通讯作者：
NARDELLIHAEFLIGER, D
影响因子：
--
作者：
Gunn, Bronwyn M.;Wanda, Soo-Young;Curtiss, Roy, III
通讯作者：
Curtiss, Roy, III
影响因子：
5.5
作者：
Husseiny, Mohamed I.;Hensel, Michael
通讯作者：
Hensel, Michael
影响因子：
2.8
作者：
Chauvaux, Sylvie;Rosso, Marie-Laure;Carniel, Elisabeth
通讯作者：
Carniel, Elisabeth
DOI：
10.1016/b978-012491543-5/50060-7
发表时间：
2005-01-01
期刊：
MUCOSAL IMMUNOLOGY, 3RD EDITION
影响因子：
--
作者：
Curtiss, Roy, III
通讯作者：
Curtiss, Roy, III