Taste preference changes throughout different life stages in male rats.
Taste preference changes throughout different life stages in male rats.
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DOI：
10.1371/journal.pone.0181650
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Iwai Y
中科院分区：
文献类型：
--
作者：
Inui-Yamamoto C;Yamamoto T;Ueda K;Nakatsuka M;Kumabe S;Inui T;Iwai Y
味觉偏好是食物选择的关键组成部分，随着年龄的增长而变化。然而，目前尚不清楚这是如何发生的。为了确定处于不同生命阶段的大鼠之间的味觉偏好差异，我们使用双瓶试验检查了味觉溶液和水的消耗。使用不同年龄的雄性Sprague-Dawley大鼠：幼年（3-6周）、年轻成年（8-11周）、成年（17-20周）、中年（34-37周）和老年（69-72周）。测量同时存在的高浓度和低浓度溶液的摄入量。我们观察到，老年组有较低的偏好比0.3 M蔗糖和0.1 M味精与其他组相比。中年组对0.03 mM QHCl的偏好率高于三个年轻组，老年组高于青少年组。盐酸和氯化钠的口味偏好没有显着不同的年龄组。老年组倾向于喜欢高浓度的蔗糖，QHCl，NaCl和味精低浓度，表明年龄相关的味觉敏感性下降。我们的目的还在于研究不同的生命阶段之间的电生理反应的鼓索神经，外周味觉神经之一，味觉刺激。电生理记录显示，年龄并没有改变鼓索神经的功能。这项研究表明，衰老会导致味觉偏好的改变。这些变化很可能是其他外周味觉神经、胃肠系统或中枢神经系统功能变化的结果。
Taste preference, a key component of food choice, changes with aging. However, it remains unclear how this occurs. To determine differences in taste preference between rats in different life stages, we examined the consumption of taste solutions and water using a two-bottle test. Male Sprague-Dawley rats of different ages were used: juvenile (3–6 weeks), young adult (8–11 weeks), adult (17–20 weeks), middle-aged (34–37 weeks), and old-aged (69–72 weeks). The intakes of the high and low concentration solutions presented simultaneously were measured. We observed that the old-aged group had lower preference ratios for 0.3 M sucrose and 0.1 M MSG in comparison with other groups. The preference ratio for 0.03 mM QHCl was higher in the middle-aged group than in the three younger groups and higher in the old-aged group than the juvenile group. The taste preferences for HCl and NaCl did not significantly differ among the age groups. The old-aged group tended to prefer high concentrations of sucrose, QHCl, NaCl, and MSG to low concentrations, indicating age-related decline in taste sensitivity. We also aimed to investigate differences between life stages in the electrophysiological responses of the chorda tympani nerve, one of the peripheral gustatory nerves, to taste stimuli. The electrophysiological recordings showed that aging did not alter the function of the chorda tympani nerve. This study showed that aging induced alterations in taste preference. It is likely that these alterations are a result of functional changes in other peripheral taste nerves, the gastrointestinal system, or the central nervous system.
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DOI：
10.1080/01639360802261862
发表时间：
2008-01-01
期刊：
Journal of Nutrition for the Elderly
影响因子：
--
作者：
Murphy, Claire
通讯作者：
Murphy, Claire
影响因子：
15.9
作者：
HILL, DL;MISTRETTA, CM
通讯作者：
MISTRETTA, CM
影响因子：
3.5
作者：
Mojet, J;Christ-Hazelhof, E;Heidema, J
通讯作者：
Heidema, J
影响因子：
--
作者：
BEIDLER, LM;FISHMAN, IY;HARDIMAN, CW
通讯作者：
HARDIMAN, CW
影响因子：
2.9
作者：
Ackroff, Karen;Weintraub, Rachel;Sclafani, Anthony
通讯作者：
Sclafani, Anthony