Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.

Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.
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DOI:
10.1038/nn.2230
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发表时间:
2009-01
影响因子:
25
通讯作者:
Scanziani, Massimo
Scanziani, Massimo
中科院分区:
医学1区
文献类型:
--
作者:
Glickfeld, Lindsey L.;Roberts, J. David;Somogyi, Peter;Scanziani, Massimo

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虽然GABA能中间神经元是皮质中突触抑制的主要来源,但已显示GABAA受体的活化可使特定神经元隔室去活化,从而导致兴奋。通过使用一种非侵入性的方法来监测个别interneurons对锥体细胞群的影响,我们发现,大鼠海马interneurons超极化锥体细胞,无论其突触的位置沿着体树突轴。
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABAA receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.
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