Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease.
Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease.
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DOI：
10.1016/j.kint.2017.06.028
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发表时间：
2018-01
影响因子：
19.6
通讯作者：
Coresh J
中科院分区：
文献类型：
--
作者：
Rebholz CM;Selvin E;Liang M;Ballantyne CM;Hoogeveen RC;Aguilar D;McEvoy JW;Grams ME;Coresh J
半乳糖凝集素-3已被提出作为心力衰竭和心脏纤维化的新生物标志物，并且还可能与其他器官如肾脏的纤维化相关。为了确定这一点，我们前瞻性地分析了来自9,148名社区动脉粥样硬化风险（ARIC）研究参与者的数据，这些参与者测量了血浆半乳糖凝集素-3水平（基线，第4次访视，1996-98年），并且没有流行的慢性肾脏疾病（CKD）或心力衰竭。截至2013年12月31日，我们确定了1，983例CKD病例，中位随访时间为16年。在基线时，半乳糖凝集素-3与估计的肾小球滤过率和尿白蛋白/肌酐比值呈横断面相关;两者均具有显著性。结果经过年龄、性别、种族中心、教育、体力活动、吸烟状况、体重指数、收缩压、抗高血压药物使用、心血管疾病史、糖尿病、空腹血糖和rs 4644（galactin-3的单核苷酸多态性）调整。半乳糖凝集素-3与CKD事件之间存在显著、分级和正相关性（四分位数4 vs. 1风险比：2.22（95%置信区间：1.89，2.60））。这种相关性减弱，但在校正估计的肾小球滤过率、尿白蛋白/肌酐比值、肌钙蛋白T和N-末端脑钠肽前体后仍然显著（四分位数4 vs. 1风险比：1.75（95%置信区间：1.49，2.06）），并且在基线高血压患者中更强（显著相互作用）。因此，在这个以社区为基础的人群中，较高的血浆半乳糖凝集素-3水平与发生CKD的风险升高相关，特别是在高血压患者中。
Galectin-3 has been proposed as a novel biomarker of heart failure and cardiac fibrosis, and may also be associated with fibrosis of other organs such as the kidney. To determine this, we prospectively analyzed data from 9,148 Atherosclerosis Risk in Communities (ARIC) Study participants with measured plasma galectin-3 levels (baseline, visit 4, 1996-98) and without prevalent chronic kidney disease (CKD) or heart failure. We identified 1,983 incident CKD cases through December 31, 2013 over a median follow-up of 16 years. At baseline, galectin-3 was cross-sectionally associated with estimated glomerular filtration rate and urine albumin-to-creatinine ratio; both significant. The results were adjusted for age, sex, race-center, education, physical activity, smoking status, body mass index, systolic blood pressure, anti-hypertensive medication use, history of cardiovascular disease, diabetes, fasting blood glucose, and rs4644 (a single nucleotide polymorphism of galactin-3). There was a significant, graded, and positive association between galectin-3 and incident CKD (quartile 4 vs. 1 hazard ratio: 2.22 (95% confidence interval: 1.89, 2.60)). The association was attenuated but remained significant after adjustment for estimated glomerular filtration rate, urine albumin-to-creatinine ratio, troponin T, and N-terminal pro-brain natriuretic peptide (quartile 4 vs. 1 hazard ratio: 1.75 (95% confidence interval: 1.49, 2.06)), and was stronger among those with hypertension at baseline (significant interaction). Thus, in this community-based population, higher plasma galectin-3 levels were associated with an elevated risk of developing incident CKD, particularly among those with hypertension.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
5.5
作者：
通讯作者：
--
影响因子：
13.2
作者：
Grams, Morgan E.;Rebholz, Casey M.;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
3.7
作者：
Kolatsi-Joannou M;Price KL;Winyard PJ;Long DA
通讯作者：
Long DA
影响因子：
13.6
作者：
Drechsler, Christiane;Delgado, Graciela;de Boer, Rudolf A.
通讯作者：
de Boer, Rudolf A.