The QTN program and the alleles that matter for evolution: all that's gold does not glitter.
The QTN program and the alleles that matter for evolution: all that's gold does not glitter.
复制标题
DOI：
10.1111/j.1558-5646.2011.01486.x
复制
发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Rockman MV
中科院分区：
文献类型：
--
作者：
Rockman MV
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie heritable variation within populations and divergence among them, is a popular pursuit. But what is the question to which QTNs are the answer? Though their pursuit is often invoked as a means of addressing the molecular basis of phenotypic evolution or of estimating the roles of evolutionary forces, the QTNs that are accessible to experimentalists, QTNs of relatively large effect, may be uninformative about these issues if large-effect variants are unrepresentative of the alleles that matter. Though 20th century evolutionary biology generally viewed large-effect variants as atypical, the field has recently undergone a quiet realignment toward a view of readily discoverable large-effect alleles as the primary molecular substrates for evolution. I argue that neither theory nor data justify this realignment. Models and experimental findings covering broad swaths of evolutionary phenomena suggest that evolution often acts via large numbers of small-effect polygenes, individually undetectable. Moreover, these small-effect variants are different in kind, at the molecular level, from the large-effect alleles accessible to experimentalists. Though discoverable quantitative trait nucleotides address some fundamental evolutionary questions, they are essentially misleading about many others.
登录
查看更多内容
影响因子：
64.8
作者：
Bendesky, Andres;Tsunozaki, Makoto;Rockman, Matthew V.;Kruglyak, Leonid;Bargmann, Cornelia I.
通讯作者：
Bargmann, Cornelia I.
影响因子：
4.4
作者：
Cicila, GT;Garrett, MR;Rapp, JP
通讯作者：
Rapp, JP
影响因子：
1.5
作者：
Crow, James F.
通讯作者：
Crow, James F.
影响因子：
3.3
作者：
Daetwyler, Hans D.;Pong-Wong, Ricardo;Woolliams, John A.
通讯作者：
Woolliams, John A.
DOI：
10.1073/pnas.0705140104
发表时间：
2007-07-24
影响因子：
11.1
作者：
Asthana, Saurabh;Noble, William S.;Stamatoyannopoulos, John A.
通讯作者：
Stamatoyannopoulos, John A.