Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation.
Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation.
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DOI：
10.7150/jca.16884
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发表时间：
2016
影响因子：
3.9
通讯作者：
Daniele A
中科院分区：
文献类型：
--
作者：
Divella R;De Luca R;Abbate I;Naglieri E;Daniele A
脂肪组织除了保持脂质的能力外，现在被认为是一个具有代谢和内分泌功能的真实的器官。最近的研究表明，在肥胖动物中建立了脂肪细胞缺氧的状态，在这种缺氧状态下，脂肪细胞和基质血管细胞之间的相互作用有助于肿瘤的发生和发展。在乳腺、结肠、肝脏和前列腺等几种肿瘤中，肥胖是临床结果的不良预测因素。肥胖症中的功能障碍性脂肪组织释放出脂肪因子的紊乱谱，促炎因子水平升高，从而改变关键信号传导介质，其可能是建立促进肿瘤生长和进展的肿瘤周围环境的积极局部参与者。因此，脂肪组织缺氧可能有助于肥胖人群的癌症风险。到目前为止，肥胖与癌症之间联系背后的确切机制尚未完全了解。根据本综述中提供的信息，旨在确定肥胖和癌症之间联系的关键机制，我们支持肥胖特异性炎症状态在肥胖-癌症联系中可能很重要。
Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with both metabolic and endocrine functions. Recent studies demonstrated that in obese animals is established a status of adipocyte hypoxia and in this hypoxic state interaction between adipocytes and stromal vascular cells contribute to tumor development and progression. In several tumors such as breast, colon, liver and prostate, obesity represents a poor predictor of clinical outcomes. Dysfunctional adipose tissue in obesity releases a disturbed profile of adipokines with elevated levels of pro-inflammatory factors and a consequent alteration of key signaling mediators which may be an active local player in establishing the peritumoral environment promoting tumor growth and progression. Therefore, adipose tissue hypoxia might contribute to cancer risk in the obese population. To date the precise mechanisms behind this obesity-cancer link is not yet fully understood. In the light of information provided in this review that aims to identify the key mechanisms underlying the link between obesity and cancer we support that inflammatory state specific of obesity may be important in obesity-cancer link.
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影响因子：
8.8
作者：
Chen, Z-Y;Raghav, K.;Lieu, C. H.;Jiang, Z-Q;Eng, C.;Vauthey, J-N;Chang, G. J.;Qiao, W.;Morris, J.;Hong, D.;Hoff, P.;Tran, H.;Menter, D. G.;Heymach, J.;Overman, M.;Kopetz, S.
通讯作者：
Kopetz, S.
DOI：
10.1016/j.bbrc.2015.04.020
发表时间：
2015-05-29
影响因子：
3.1
作者：
Bhattacharya, Indranil;Dominguez, Ana Perez;Battegay, Edouard J.
通讯作者：
Battegay, Edouard J.
影响因子：
5.8
作者：
Choi, JH;Park, SH;Choi, KC
通讯作者：
Choi, KC
DOI：
10.1152/ajpendo.00110.2003
发表时间：
2003-09-01
影响因子：
5.1
作者：
Bruun, JM;Lihn, AS;Richelsen, B
通讯作者：
Richelsen, B
影响因子：
9.7
作者：
Almendros, Isaac;Gileles-Hillel, Alex;Gozal, David
通讯作者：
Gozal, David