Design and demonstration of an intracortical probe technology with tunable modulus.
Design and demonstration of an intracortical probe technology with tunable modulus.
复制标题
DOI：
10.1002/jbm.a.35896
复制
发表时间：
2017-01
影响因子：
4.9
通讯作者：
Voit, Walter E.
中科院分区：
文献类型：
--
作者：
Simon, Dustin M.;Charkhkar, Hamid;St John, Conan;Rajendran, Sakthi;Kang, Tong;Reit, Radu;Arreaga-Salas, David;McHail, Daniel G.;Knaack, Gretchen L.;Sloan, Andrew;Grasse, Dane;Dumas, Theodore C.;Rennaker, Robert L.;Pancrazio, Joseph J.;Voit, Walter E.
关键词：
皮层内探头技术由微电极阵列组成，提供了一种记录神经组织生物电活动的方法。现有皮质内探头技术的一个主要限制涉及植入后记录的有限寿命为6个月至一年。人们普遍认为，设备故障的一个主要原因是传统的僵硬的皮质内设备与周围脑组织的界面机械不匹配。我们描述了一种新型功能性皮质内探头技术的设计、开发和演示，该探头的杨氏模数从~2 GPA可调到~50 Mpa。这项技术利用了动态软化材料的进步，特别是硫醇-烯/丙烯酸酯热固性聚合物，它们在体外软化时表现出最小的膨胀<；3%重量。我们证明，基于形状记忆聚合物的多通道皮质内探头可以被制造出来，其机械性能至少稳定2个月，并且该装置能够在体内进行长达77天的单单元记录。这项新技术适用于适合于通过标准半导体制造技术制造的工艺，提供了在体内软化的能力，以减少组织设备的模数失配，最终提高神经记录的长期生存能力。
Intracortical probe technology, consisting of arrays of microelectrodes, offers a means of recording the bioelectrical activity from neural tissue. A major limitation of existing intracortical probe technology pertains to limited lifetime of 6 months to a year of recording after implantation. A major contributor to device failure is widely believed to be the interfacial mechanical mismatch of conventional stiff intracortical devices and the surrounding brain tissue. We describe the design, development, and demonstration of a novel functional intracortical probe technology that has a tunable Young’s modulus from ~2 GPa to ~50 MPa. This technology leverages advances in dynamically softening materials, specifically thiol-ene/acrylate thermoset polymers, which exhibit minimal swelling of < 3% weight upon softening in vitro. We demonstrate that a shape memory polymer-based multichannel intracortical probe can be fabricated, that the mechanical properties are stable for at least 2 months and that the device is capable of single unit recordings for durations up to 77 days in vivo. This novel technology, which is amenable to processes suitable for manufacturing via standard semiconductor fabrication techniques, offers the capability of softening in vivo to reduce the tissue-device modulus mismatch to ultimately improve long term viability of neural recordings.
登录
查看更多内容
影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
14
作者：
Lu, Yi;Wang, Dingfang;Duan, Yanwen Y.
通讯作者：
Duan, Yanwen Y.
影响因子：
12.6
作者：
Charkhkar, Hamid;Frewin, Christopher;Pancrazio, Joseph J.
通讯作者：
Pancrazio, Joseph J.
影响因子：
2.3
作者：
Mahi, Hojjat;Rodrigue, Denis
通讯作者：
Rodrigue, Denis
影响因子：
19
作者：
Ware, Taylor;Simon, Dustin;Voit, Walter
通讯作者：
Voit, Walter