An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study.
An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study.
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骨蛋白蛋白蛋白基因多态性与日本类风湿关节炎患者的髋部骨折风险增加有关：IORRA观察群研究的结果。
DOI：
10.1371/journal.pone.0104587
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Momohara S
中科院分区：
文献类型：
--
作者：
Yoshida S;Ikari K;Furuya T;Toyama Y;Taniguchi A;Yamanaka H;Momohara S
类风湿性关节炎（RA）患者骨质疏松症和髋部骨折的患病率高于健康人群。在最近的全基因组关联研究中发现了多个与骨质疏松性骨折相关的遗传位点。本研究的目的是确定与日本RA患者髋部骨折发生相关的遗传变异。来自2，282名日本RA患者的DNA样本来自风湿性关节炎研究所（IORRA）研究的DNA收集。六个单核苷酸多态性（SNPs），已被报道与骨折在最近的研究中选择和基因分型。确定了40例髋关节骨折，最长随访10年。髋部骨折的遗传风险采用多变量考克斯比例风险回归模型进行了研究。风险分析显示，OPG基因座中SNP rs6993813主要等位基因纯合子的患者发生髋部骨折的风险更高（风险比[95%CI]= 2.53 [1.29-4.95]，P = 0.0067）。 未发现其他SNPs之间存在关联。我们的研究结果表明，OPG等位基因与日本RA患者髋部骨折的风险增加有关。
Patients with rheumatoid arthritis (RA) have a higher prevalence of osteoporosis and hip fracture than healthy individuals. Multiple genetic loci for osteoporotic fracture were identified in recent genome-wide association studies. The purpose of this study was to identify genetic variants associated with the occurrence of hip fracture in Japanese patients with RA. DNA samples from 2,282 Japanese patients with RA were obtained from the DNA collection of the Institute of Rheumatology Rheumatoid Arthritis cohort (IORRA) study. Six single nucleotide polymorphisms (SNPs) that have been reported to be associated with fractures in recent studies were selected and genotyped. Forty hip fractures were identified with a maximum follow-up of 10 years. The genetic risk for hip fracture was examined using a multivariate Cox proportional hazards regression model. The risk analyses revealed that patients who are homozygous for the major allele of SNP rs6993813, in the OPG locus, have a higher risk for hip fracture (hazard ratio [95% CI] = 2.53 [1.29–4.95], P = 0.0067). No association was found for the other SNPs. Our results indicate that an OPG allele is associated with increased risk for hip fracture in Japanese patients with RA.
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