Hippocampus, context, and conditioning.
Hippocampus, context, and conditioning.
复制标题
海马体、环境和调节。
作者：
S. Penick;P. Solomon
兔（Oryctolagus cuniculus）与病变的海马或覆盖的新皮层和未操作的控制进行收购的经典条件瞬膜反应的音调条件刺激和空气喷非条件刺激，直到他们达到一个标准的8个条件反应，在任何块10个试验。然后将它们放回笼子里。第二天，他们要么被放置在最初接受条件反射的相同环境中，要么被转换到一个沿着嗅觉、视觉和触觉方面明显不同的新环境中。与未切换的对照组相比，新皮层病变的兔子和未手术的对照组在上下文切换时表现出条件反射的中断。相比之下，海马损伤的兔子表现与未转换的对照组相同。结果进行了讨论，在经典条件反射的编码背景下，海马的可能作用。
Rabbits (Oryctolagus cuniculus) with lesions to either the hippocampus or overlying neocortex and unoperated controls underwent acquisition of the classically conditioned nictitating membrane response to a tone conditioned stimulus and an air puff unconditioned stimulus until they reached a criterion of 8 conditioned responses in any block of 10 trials. They were then returned to their cages. On the next day, they were either placed in the same context in which they underwent initial conditioning or switched to a new context that distinctly differed along olfactory, visual, and tactile dimensions. In relation to unswitched controls, rabbits with lesions to the neocortex and unoperated controls showed a disruption of conditioning when contexts were switched. In contrast, rabbits with lesions to the hippocampus performed at the same levels as unswitched controls. The results are discussed in terms of the possible role of hippocampus in coding context in classical conditioning.
影响因子：
56.9
作者：
COHEN, NJ;SQUIRE, LR
通讯作者：
SQUIRE, LR