A longitudinal study of Angiostrongylus cantonensis in an urban population of Rattus norvegicus in Brazil: the influences of seasonality and host features on the pattern of infection.
A longitudinal study of Angiostrongylus cantonensis in an urban population of Rattus norvegicus in Brazil: the influences of seasonality and host features on the pattern of infection.
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DOI：
10.1186/1756-3305-7-100
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发表时间：
2014-03-10
影响因子：
3.2
通讯作者：
Luque JL
中科院分区：
文献类型：
--
作者：
Simões RO;Maldonado Júnior A;Olifiers N;Garcia JS;Bertolino AV;Luque JL
广州管圆线虫是一种人畜共患寄生虫，也是世界范围内引起人类嗜酸性粒细胞性脑膜炎的最重要原因。在巴西，圣埃斯皮里图州和伯南布哥州报告了这种疾病。在里约热内卢州、伯南布哥州和圣卡塔里纳州的自然感染中间宿主中发现了这种寄生虫。褐家鼠Rattus norvegicus R.最近有报道说，巴西的老鼠是自然感染的。在这项研究中，我们进行了为期两年的调查，传播模式的A。cantonensis在R.在巴西里约热内卢州的一个城市地区的A. norvegicus，研究了季节性，年，主机重量和主机性别的影响，寄生虫学参数。大鼠中的广州虫。该研究在巴西里约热内卢圣贡萨洛市特林达德地区进行。感染鼠的患病率、A.通过建立广义线性模型，验证了寄主性别、寄主体重、年度和季节性对广州管蚜种群数量变化的影响。大鼠中的广州线虫丰度和患病率。A.在雨季（71%，CI 58.9- 81.6）和旱季（71%，CI 57.9-80.8），广州线虫感染率保持稳定，老年大鼠和雌性大鼠的感染率较高。季节性，主机重量（用作动物年龄的代理）和性别都是影响寄生虫丰度变化的因素，女性和较重（老年）的动物显示更大的寄生虫丰度，寄生虫丰度的极端值在旱季更频繁。在整个研究期间，这种寄生虫的高流行率表明，其传播是稳定的，并且有足够的条件将寄生虫传播到以前未受影响的地区。寄生虫向新地区的传播可能是由男性介导的，男性往往具有更大的传播能力，而女性可能对维持寄生虫在局部范围内更重要，因为她们的感染率更高。一个多学科的方法，考虑到生态分布的大鼠和中间宿主，以及环境特征，需要进一步了解管圆线虫病的动态。
The nematode Angiostrongylus cantonensis is a zoonotic parasite and the most important cause of eosinophilic meningitis worldwide in humans. In Brazil, this disease has been reported in the states of Espírito Santo and Pernambuco. The parasite has been detected in the naturally infected intermediate host, in the states of Rio de Janeiro, Pernambuco and Santa Catarina. The murid Rattus norvegicus R. rattus were recently reported to be naturally infected in Brazil. In this study, we conducted a two-year investigation of the dissemination pattern of A. cantonensis in R. norvegicus in an urban area of Rio de Janeiro state, Brazil, and examined the influence of seasonality, year, host weight and host gender on parasitological parameters of A. cantonensis in rats. The study was conducted in an area of Trindade, São Gonçalo municipality, Rio de Janeiro, Brazil. Prevalence of infected rats, intensity and abundance of A. cantonensis were calculated, and generalized linear models were created and compared to verify the contribution of host gender, host weight, year and seasonality to the variations in A. cantonensis abundance and prevalence in rats. The prevalence of A. cantonensis infection was stable during the rainy (71%, CI 58.9- 81.6) and dry seasons (71%, CI 57.9-80.8) and was higher in older rats and in females. Seasonality, host weight (used as a proxy of animal age) and gender were all contributing factors to variation in parasite abundance, with females and heavier (older) animals showing larger abundance of parasites, and extreme values of parasite abundance being more frequent in the dry season. The high prevalence of this parasite throughout the study suggests that its transmission is stable and that conditions are adequate for the spread of the parasite to previously unaffected areas. Dispersion of the parasite to new areas may be mediated by males that tend to have larger dispersal ability, while females may be more important for maintaining the parasite on a local scale due to their higher prevalence and abundance of infection. A multidisciplinary approach considering the ecological distribution of the rats and intermediate hosts, as well as environmental features is required to further understand the dynamics of angiostrongyliasis.
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影响因子：
1.4
作者：
Dorta-Contreras, Alberto J.;Padilla-Docal, Barbara;Bu-Coifiu- Fanego, Raisa
通讯作者：
Bu-Coifiu- Fanego, Raisa
DOI：
10.4269/ajtmh.1981.30.963
发表时间：
1981-01-01
影响因子：
3.3
作者：
AGUIAR, PH;MORERA, P;PASCUAL, J
通讯作者：
PASCUAL, J
影响因子：
2.7
作者：
Krasnov, BR;Morand, S;Shenbrot, GI
通讯作者：
Shenbrot, GI
影响因子：
1.6
作者：
Abu-Madi, MA;Behnke, JM;Al-Kaabi, ML
通讯作者：
Al-Kaabi, ML
影响因子：
3.2
作者：
Monte TC;Simões RO;Oliveira AP;Novaes CF;Thiengo SC;Silva AJ;Estrela PC;Maldonado A Jr
通讯作者：
Maldonado A Jr