Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats
Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats
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自发性高血压和正常血压大鼠离体肝细胞抗氧化防御机制和过氧化的年龄相关变化
DOI：
10.1007/bf00925671
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发表时间：
1994
影响因子：
4.3
通讯作者：
M. Lagarde
中科院分区：
文献类型：
--
作者：
E. Véricel;M. Narce;L. Ulmann;J. Poisson;M. Lagarde
本文研究了年龄和高血压对大鼠离体肝细胞抗氧化防御系统和脂质过氧化的影响。自发性高血压大鼠(SHR)和血压正常的Wistar-京都(WKY)大鼠分为4个不同年龄组(1、3、6、12个月)。观察了两种菌株维生素E状态、谷胱甘肽(GSH)水平、丙二醛(MDA)生成和谷胱甘肽过氧化物酶(GSH-Px)活性随年龄的变化。除丙二醛在3个月时较低外，其余指标均在3个月和6个月时达到最高水平或活性。然后，观察到12个月大的婴儿与6个月大的婴儿相比有所下降。此外，除1月龄外，自发性高血压大鼠GSH-Px活性显著低于WKY大鼠。该酶活性的降低可导致细胞内自由基生成增加和脂质过氧化，这可能与高血压有关。
The effects of age and hypertension on the antioxidant defence systems and the lipid peroxidation in rat isolated hepatocytes were studied. Four different age groups (1,3,6 and 12 months) were considered in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Age-associated changes were observed on vitamin E status, glutathione (GSH) level, MDA formation and glutathione peroxidase (GSH-Px) activity in both strains. Maximal levels or activities of these parameters were found at 3 and 6 months, except for MDA which was low at 3 months. Then, a fall was observed at 12-month-old compared to 6-month values. In addition, GSH-Px activity was significantly lower in SHR than in WKY rats, except at the age of one month. The decrease of this enzyme activity could induce an increased cellular generation of radical species and lipid peroxidation, which might be link to hypertension.
DOI：
--
发表时间：
1989-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
N. Avissar;J. Whitin;P. Allen;D. Wagner;P. Liegey;H. Cohen
通讯作者：
N. Avissar;J. Whitin;P. Allen;D. Wagner;P. Liegey;H. Cohen
恒河猴晶状体中谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽-S-转移酶的活性与年龄的关系。
影响因子：
2
作者：
Rathbun,WB;Bovis,MG;Holleschau,AM
通讯作者：
Holleschau,AM
衰老对大鼠肝脏抗氧化防御机制影响的性别依赖性差异。
DOI：
10.1016/0304-4165(91)90061-k
发表时间：
1991
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Rikans,LE;Moore,DR;Snowden,CD
通讯作者：
Snowden,CD